Preclinical validation of a repurposed metal chelator as an early-intervention therapeutic for hemotoxic snakebite.

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作者： Laura-Oana,Albulescu ^[1] ; Melissa S,Hale ^[1] ; Stuart,Ainsworth ^[1] ; Jaffer,Alsolaiss ^[1] ; Edouard,Crittenden ^[1] ; Juan J,Calvete ^[2] ; Chloe,Evans ^[1] ; Mark C,Wilkinson ^[1] ; Robert A,Harrison ^[3] ; Jeroen,Kool ^[4] ; Nicholas R,Casewell ^[5]

作者单位： Centre for Snakebite Research and Interventions, Liverpool School of Tropical Medicine, Pembroke Place, L3 5QA Liverpool, UK. ^[1] Laboratorio de Venómica Estructural y Funcional, Instituto de Biomedicina de Valencia, CSIC, Valencia 46010, Spain. ^[2] Centre for Snakebite Research and Interventions, Liverpool School of Tropical Medicine, Pembroke Place, L3 5QA Liverpool, UK.;Centre for Drugs and Diagnostics, Liverpool School of Tropical Medicine, Pembroke Place, L3 5QA Liverpool, UK. ^[3] Amsterdam Institute for Molecules Medicines and Systems, Division of BioAnalytical Chemistry, Department of Chemistry and Pharmaceutical Sciences, Faculty of Sciences, Vrije Universiteit Amsterdam, De Boelelaan 1083, 1081HV Amsterdam, Netherlands. ^[4] Centre for Snakebite Research and Interventions, Liverpool School of Tropical Medicine, Pembroke Place, L3 5QA Liverpool, UK. nicholas.casewell@lstmed.ac.uk.;Centre for Drugs and Diagnostics, Liverpool School of Tropical Medicine, Pembroke Place, L3 5QA Liverpool, UK. ^[5]