Elevated pigment epithelium-derived factor induces diabetic erectile dysfunction via interruption of the Akt/Hsp90β/eNOS complex.

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第一作者： Di,Che

第一单位： Program of Molecular Medicine, Affiliated Guangzhou Women and Children's Hospital, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.

作者： Di,Che ^[1] ; Zhenzhen,Fang ^[2] ; Li,Yan ^[3] ; Jieping,Du ^[2] ; Fangping,Li ^[4] ; Jinye,Xie ^[4] ; Juan,Feng ^[4] ; Ping,Yin ^[2] ; Weiwei,Qi ^[2] ; Zhonghan,Yang ^[2] ; Jianxing,Ma ^[2] ; Xia,Yang ^[2] ; Guoquan,Gao ^[5] ; Ti,Zhou ^[6]

作者单位： Program of Molecular Medicine, Affiliated Guangzhou Women and Children's Hospital, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China. ^[1] Department of Biochemistry, Zhongshan School of Medicine, Sun Yat-sen University, 74 Zhongshan Road II, Guangzhou, 510080, China. ^[2] Department of Clinical Biological Resource Bank, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou, China. ^[3] Department of Endocrinology, Second Affiliated Hospital, Sun Yat-sen University, Guangzhou, China. ^[4] Department of Physiology, University of Oklahoma, Health Sciences Center, Oklahoma City, OK, USA. ^[5] Program of Molecular Medicine, Affiliated Guangzhou Women and Children's Hospital, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China. yangxia@mail.sysu.edu.cn. ^[6] Department of Biochemistry, Zhongshan School of Medicine, Sun Yat-sen University, 74 Zhongshan Road II, Guangzhou, 510080, China. yangxia@mail.sysu.edu.cn. ^[7] Guangdong Engineering & Technology Research Center for Gene Manipulation and Biomacromolecular Products, Sun Yat-sen University, Guangzhou, China. yangxia@mail.sysu.edu.cn. ^[8] Program of Molecular Medicine, Affiliated Guangzhou Women and Children's Hospital, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China. gaogq@mail.sysu.edu.cn. ^[9] Department of Biochemistry, Zhongshan School of Medicine, Sun Yat-sen University, 74 Zhongshan Road II, Guangzhou, 510080, China. gaogq@mail.sysu.edu.cn. ^[10] Guangdong Province Key Laboratory of Brain Function and Disease, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China. gaogq@mail.sysu.edu.cn. ^[11] Program of Molecular Medicine, Affiliated Guangzhou Women and Children's Hospital, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China. zhouti2@mail.sysu.edu.cn. ^[12] Department of Biochemistry, Zhongshan School of Medicine, Sun Yat-sen University, 74 Zhongshan Road II, Guangzhou, 510080, China. zhouti2@mail.sysu.edu.cn. ^[13]

关键词 Diabetes mellitus erectile dysfunction DMED Endothelial cells? eNOS Hsp90β PEDF Pigment epithelium-derived factor