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Opportunities for multiscale computational modelling of serotonergic drug effects in Alzheimer's disease.

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第一作者： Alok,Joshi

第一单位： Intelligent Systems Research Centre, Ulster University, Derry~Londonderry, Northern Ireland, UK. Electronic address: a.joshi@ulster.ac.uk.

作者： Alok,Joshi ^[1] ; Da-Hui,Wang ^[2] ; Steven,Watterson ^[3] ; Paula L,McClean ^[3] ; Chandan K,Behera ^[4] ; Trevor,Sharp ^[5] ; KongFatt,Wong-Lin ^[6]

作者单位： Intelligent Systems Research Centre, Ulster University, Derry~Londonderry, Northern Ireland, UK. Electronic address: a.joshi@ulster.ac.uk. ^[1] State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China; School of System Science, Beijing Normal University, Beijing, China. ^[2] Northern Ireland Centre for Stratified Medicine, Biomedical Sciences Research Institute, Ulster University, Derry~Londonderry, Northern Ireland, UK. ^[3] Intelligent Systems Research Centre, Ulster University, Derry~Londonderry, Northern Ireland, UK. ^[4] Department of Pharmacology, University of Oxford, Oxford, UK. ^[5] Intelligent Systems Research Centre, Ulster University, Derry~Londonderry, Northern Ireland, UK. Electronic address: k.wong-lin@ulster.ac.uk. ^[6]

关键词 Alzheimer's disease Beta-amyloid Boolean models Data-driven models Dementia GSK-3 Knowledge-driven models Mechanistic models Multiscale computational modelling Serotonin Serotonin targeted drugs Tau

医学主题词阿尔茨海默病(Alzheimer Disease);动物(Animals);人类(Humans);受体, 血清素(Receptors, Serotonin);血清素类药(Serotonin Agents);治疗结果(Treatment Outcome)

DOI 10.1016/j.neuropharm.2020.108118

PMID 32380022

发布时间 2024-07-30

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