Glucocorticoids rapidly inhibit cell migration through a novel, non-transcriptional HDAC6 pathway.

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第一作者： Stephen,Kershaw

第一单位： Systems Oncology, Cancer Research UK Manchester Institute, Manchester, SK10 4TG, UK.

作者： Stephen,Kershaw ^[1] ; David J,Morgan ^[2] ; James,Boyd ^[3] ; David G,Spiller ^[4] ; Gareth,Kitchen ^[5] ; Egor,Zindy ^[6] ; Mudassar,Iqbal ^[7] ; Magnus,Rattray ^[7] ; Christopher M,Sanderson ^[7] ; Andrew,Brass ^[4] ; Claus,Jorgensen ^[7] ; Tracy,Hussell ^[1] ; Laura C,Matthews ^[2] ; David W,Ray ^[3]

作者单位： Systems Oncology, Cancer Research UK Manchester Institute, Manchester, SK10 4TG, UK. ^[1] Manchester Collaborative Centre for Inflammation Research, University of Manchester, Manchester, M13 9PT, UK. ^[2] Lydia Becker Institute of Immunology and Inflammation University of Manchester, Manchester, M13 9PT, UK. ^[3] Division of Cellular and Molecular Physiology, University of Liverpool, Liverpool, L69 3BX, UK. ^[4] Platform Sciences, Enabling Technologies, and Infrastructure, University of Manchester, Manchester, M13 9PT, UK. ^[5] Division of Diabetes, Endocrinology, and Gastroenterology, University of Manchester, Manchester, M13 9PT, UK. ^[6] Division of Informatics, Imaging, and Data Sciences, Faculty of Biology, Medicine, and Health, University of Manchester, Manchester, M13 9PT, UK. ^[7] Leeds Institute of Cancer and Pathology, Faculty of Medicine and Health, University of Leeds, Leeds, LS2 9JT, UK. ^[8] Division of Diabetes, Endocrinology, and Gastroenterology, University of Manchester, Manchester, M13 9PT, UK david.ray@ocdem.ox.ac.uk. ^[9] Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), University of Oxford, OX3 7LE, and NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, OX3 9DU, UK. ^[10]

关键词 Cell migration Glucocorticoid HDAC6 Microtubule Quantitative imaging

主题词细胞运动(Cell Movement);胞质溶胶(Cytosol);基因表达(Gene Expression);糖皮质激素类(Glucocorticoids);受体, 糖皮质激素(Receptors, Glucocorticoid)

DOI 10.1242/jcs.242842

PMID 32381682

发布时间 2024-02-10

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