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The scaffold protein p62 regulates adaptive thermogenesis through ATF2 nuclear target activation.

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作者单位: Institute for Diabetes and Obesity, Helmholtz Diabetes Center (HDC), Helmholtz Zentrum München and German National Diabetes Center (DZD), 85764, Neuherberg, Germany. [1] Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN, 37232, USA. [2] Division of Metabolic Diseases, Department of Medicine, Technische Universität München, 80333, Munich, Germany. [3] Section of Molecular Physiology, Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, 2200, Copenhagen, Denmark. [4] Research Unit Comparative Medicine, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, Neuherberg, Germany. [5] Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, 2200, Copenhagen, Denmark. [6] Novo Nordisk Research Center, Indianapolis, IN, 46241, USA. [7] Institute of Clinical Microbiology and Hygiene, University Hospital Regensburg, Neuherberg, Germany. [8] Department of Molecular Biosciences, The Wenner-Gren Institute, The Arrhenius Laboratories F3, Stockholm University, SE-106 91, Stockholm, Sweden. [9] Cancer Metabolism and Signaling Networks Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, 92037, USA. [10] Chair of Molecular Nutritional Medicine, Technical University of Munich, TUM School of Life Sciences Weihenstephan, Gregor-Mendel-Strasse 2, D-85354, Freising, Germany. [11] EKFZ-Else-Kröner Fresenius Center for Nutritional Medicine, Technical University of Munich, Gregor-Mendel-Strasse 2, D-85354, Freising, Germany. [12] Department of Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research, Gleueler Strasse 50, 50931, Cologne, Germany. [13] Policlinic for Endocrinology, Diabetes and Preventive Medicine (PEDP), University Hospital Cologne, Kerpener Strasse 26, 50924, Cologne, Germany. [14] Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) and Center for Molecular Medicine Cologne (CMMC), University of Cologne, Joseph-Stelzmann-Strasse 26, 50931, Cologne, Germany. [15] Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University Tübingen, Tübingen, Germany. [16] Department of Dermatology, Eberhard Karls University Tübingen, 72076, Tübingen, Germany. [17] Department of Diagnostic and Interventional Radiology, Eberhard Karls University Hospital Tübingen, Hoppe-Seyler-Straße 3, 72076, Tübingen, Germany. [18] Metabolic Disease Institute, Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati, Cincinnati, OH, 45237, USA. [19] Department of Biology, University of Konstanz, Konstanz, Germany. [20] Institute for Diabetes and Obesity, Helmholtz Diabetes Center (HDC), Helmholtz Zentrum München and German National Diabetes Center (DZD), 85764, Neuherberg, Germany. timo.mueller@helmholtz-muenchen.de. [21] Institute of Experimental and Clinical Pharmacology and Pharmacogenomics, Department of Pharmacology, Experimental Therapy and Toxicology, Eberhard Karls University Hospitals and Clinics, 72076, Tübingen, Germany. timo.mueller@helmholtz-muenchen.de. [22]
DOI 10.1038/s41467-020-16230-8
PMID 32385399
发布时间 2021-06-04
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