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Unblending of Transcriptional Condensates in Human Repeat Expansion Disease.

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第一作者： Shaon,Basu

第一单位： Department of Genome Regulation, Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany.

作者： Shaon,Basu ^[1] ; Sebastian D,Mackowiak ^[1] ; Henri,Niskanen ^[1] ; Dora,Knezevic ^[1] ; Vahid,Asimi ^[1] ; Stefanie,Grosswendt ^[1] ; Hylkje,Geertsema ^[2] ; Salaheddine,Ali ^[3] ; Ivana,Jerković ^[4] ; Helge,Ewers ^[2] ; Stefan,Mundlos ^[3] ; Alexander,Meissner ^[5] ; Daniel M,Ibrahim ^[3] ; Denes,Hnisz ^[6]

作者单位： Department of Genome Regulation, Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany. ^[1] Institute for Chemistry and Biochemistry, Free University Berlin, 14195 Berlin, Germany. ^[2] RG Development and Disease, Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany; Institute for Medical and Human Genetics, Charité Universitätsmedizin Berlin, 13353 Berlin, Germany; Charité-Universitätsmedizin Berlin, BCRT-Berlin Institute of Health Center for Regenerative Therapies, 10178 Berlin, Germany. ^[3] RG Development and Disease, Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany. ^[4] Department of Genome Regulation, Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA. ^[5] Department of Genome Regulation, Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany. Electronic address: hnisz@molgen.mpg.de. ^[6]

关键词 activation domain condensate intrinscially disordered region phase separation repeat expansion synpolydactyly transcription factor transcriptional condensate