首页> Immunobiology> GTS-21, an α7nAChR agonist, suppressed the production of key inflammatory mediators by PBMCs that are elevated in COPD patients and associated with impaired lung function.

GTS-21, an α7nAChR agonist, suppressed the production of key inflammatory mediators by PBMCs that are elevated in COPD patients and associated with impaired lung function.

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第一作者： Sana,Douaoui

第一单位： USTHB, Cytokines and NO Synthases' Team, LBCM, FSB, Algiers, Algeria; Faculty of Sciences, Department of Life and Natural Sciences, University of Medea, Algeria.

作者： Sana,Douaoui ^[1] ; Reda,Djidjik ^[2] ; Mokhtar,Boubakeur ^[3] ; Merzak,Ghernaout ^[3] ; Chafia,Touil-Boukoffa ^[4] ; Mustapha,Oumouna ^[5] ; Fawzi,Derrar ^[6] ; Yassine,Amrani ^[7]

作者单位： USTHB, Cytokines and NO Synthases' Team, LBCM, FSB, Algiers, Algeria; Faculty of Sciences, Department of Life and Natural Sciences, University of Medea, Algeria. ^[1] Department of Immunology, Issaad Hassani Hospital, Beni Messous, Algiers, Algeria. ^[2] Department of Pneumology & Phtisiology, and Allergology, Rouiba Hospital, Algiers, University of Algiers 1, Faculty of Medicine, Algiers, Algeria. ^[3] USTHB, Cytokines and NO Synthases' Team, LBCM, FSB, Algiers, Algeria. ^[4] Faculty of Sciences, Department of Life and Natural Sciences, University of Medea, Algeria. ^[5] National Influenza Centre, Viral Respiratory Laboratory, Pasteur Institute, Algiers, Algeria. ^[6] Department of Respiratory Sciences, Institute of Lung Health and NIHR Leicester BRC-Respiratory, Glenfield Hospital, University of Leicester, Leicester, UK. Electronic address: ya26@le.ac.uk. ^[7]

关键词 COPD pathogenesis IL-6 Nicotinic receptors Nitric oxide Systemic inflammation