Pharmacokinetics/pharmacodynamics of antipseudomonal bacteriophage therapy in rats: a proof-of-concept study.

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作者： Y W,Lin ^[1] ; R Yoon,Chang ^[2] ; G G,Rao ^[3] ; B,Jermain ^[3] ; M-L,Han ^[4] ; J X,Zhao ^[4] ; K,Chen ^[4] ; J P,Wang ^[4] ; J J,Barr ^[5] ; R Turner,Schooley ^[6] ; E,Kutter ^[7] ; H-K,Chan ^[2] ; J,Li ^[8]

作者单位： Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton, VIC, Australia. Electronic address: yu-wei.lin@monash.edu. ^[1] Advanced Drug Delivery Group, School of Pharmacy, The University of Sydney Faculty of Medicine and Health, Sydney, NSW, Australia. ^[2] Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, USA. ^[3] Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton, VIC, Australia. ^[4] School of Biological Sciences, Monash University, Clayton, VIC, Australia. ^[5] Division of Infectious Diseases and Global Public Health, Department of Medicine, University of California San Diego, La Jolla, CA, USA. ^[6] The Evergreen State College, Olympia, WA, USA. ^[7] Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton, VIC, Australia. Electronic address: jian.li@monash.edu. ^[8]

关键词 Antibiotic resistance Gram-negative bacteria Phage therapy Pharmacokinetics/Pharmacodynamics Pseudomonas aeruginosa

主题词动物(Animals);细菌噬菌体(Bacteriophages);抗药性, 多种, 细菌(Drug Resistance, Multiple, Bacterial);铜绿假单胞菌(Pseudomonas aeruginosa);大鼠(Rats);大鼠, Sprague-Dawley(Rats, Sprague-Dawley)

DOI 10.1016/j.cmi.2020.04.039

PMID 32387436

发布时间 2022-03-07

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