Negative allosteric modulation of GluN1/GluN3 NMDA receptors.

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作者： Zongjian,Zhu ^[1] ; Feng,Yi ^[2] ; Matthew P,Epplin ^[3] ; Ding,Liu ^[4] ; Samantha L,Summer ^[3] ; Ruth,Mizu ^[4] ; Gil,Shaulsky ^[4] ; Wenshu,XiangWei ^[4] ; Weiting,Tang ^[4] ; Pieter B,Burger ^[3] ; David S,Menaldino ^[3] ; Scott J,Myers ^[4] ; Dennis C,Liotta ^[3] ; Kasper B,Hansen ^[2] ; Hongjie,Yuan ^[4] ; Stephen F,Traynelis ^[5]

作者单位： Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, GA, 30322, USA; Department of Neonatology, First Affiliated Hospital of Xi'an Jiaotong University, 710061, Xi'an, Shaanxi, China. ^[1] Center for Structural and Functional Neuroscience, Center for Biomolecular Structure and Dynamics, Division of Biological Sciences, University of Montana, Missoula, MT, 59812, USA. ^[2] Department of Chemistry, Emory University, Atlanta, GA, 30322, USA. ^[3] Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, GA, 30322, USA. ^[4] Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, GA, 30322, USA. Electronic address: strayne@emory.edu. ^[5]

关键词 GluN3A subunit N-methyl-d-aspartate (NMDA) receptors Negative allosteric modulator Non-competitive antagonist Site of action