首页> Nature medicine> T cell-inducing vaccine durably prevents mucosal SHIV infection even with lower neutralizing antibody titers.

T cell-inducing vaccine durably prevents mucosal SHIV infection even with lower neutralizing antibody titers.

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第一作者： Prabhu S,Arunachalam

第一单位： Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford University, Stanford, CA, USA.

作者： Prabhu S,Arunachalam ^[1] ; Tysheena P,Charles ^[2] ; Vineet,Joag ^[3] ; Venkata S,Bollimpelli ^[4] ; Madeleine K D,Scott ^[5] ; Florian,Wimmers ^[1] ; Samantha L,Burton ^[2] ; Celia C,Labranche ^[6] ; Caroline,Petitdemange ^[7] ; Sailaja,Gangadhara ^[4] ; Tiffany M,Styles ^[4] ; Clare F,Quarnstrom ^[3] ; Korey A,Walter ^[8] ; Thomas J,Ketas ^[9] ; Traci,Legere ^[4] ; Pradeep Babu,Jagadeesh Reddy ^[10] ; Sudhir Pai,Kasturi ^[11] ; Anthony,Tsai ^[12] ; Bertrand Z,Yeung ^[12] ; Shakti,Gupta ^[13] ; Mark,Tomai ^[14] ; John,Vasilakos ^[15] ; George M,Shaw ^[16] ; Chil-Yong,Kang ^[17] ; John P,Moore ^[9] ; Shankar,Subramaniam ^[13] ; Purvesh,Khatri ^[5] ; David,Montefiori ^[6] ; Pamela A,Kozlowski ^[8] ; Cynthia A,Derdeyn ^[18] ; Eric,Hunter ^[19] ; David,Masopust ^[20] ; Rama R,Amara ^[21] ; Bali,Pulendran ^[22]

作者单位： Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford University, Stanford, CA, USA. ^[1] Department of Pathology and Laboratory Medicine, Emory Vaccine Center, Yerkes National Primate Research Center, Atlanta, GA, USA. ^[2] Department of Microbiology and Immunology, Center for Immunology, University of Minnesota, Minneapolis, MN, USA. ^[3] Department of Microbiology and Immunology, Emory Vaccine Center, Yerkes National Primate Research Center at Emory University, Atlanta, GA, USA. ^[4] Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford University, Stanford, CA, USA.;Center for Biomedical Informatics, Department of Medicine, Stanford University, Stanford, CA, USA. ^[5] Department of Surgery, Duke University School of Medicine, Durham, NC, USA. ^[6] Department of Microbiology and Immunology, Emory Vaccine Center, Yerkes National Primate Research Center at Emory University, Atlanta, GA, USA.;HIV Inflammation and Persistence Unit, Institut Pasteur, Paris, France. ^[7] Department of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center, New Orleans, LA, USA. ^[8] Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY, USA. ^[9] Department of Microbiology and Immunology, Emory Vaccine Center, Yerkes National Primate Research Center at Emory University, Atlanta, GA, USA.;Pfizer, Andover, MA, USA. ^[10] Department of Pathology and Laboratory Medicine, Emory Vaccine Center, Yerkes National Primate Research Center, Atlanta, GA, USA.;Department of Microbiology and Immunology, Emory Vaccine Center, Yerkes National Primate Research Center at Emory University, Atlanta, GA, USA. ^[11] BioLegend, San Diego, CA, USA. ^[12] Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA. ^[13] 3M Corporate Research and Materials Lab, Saint Paul, MN, USA. ^[14] 3M Drug Delivery Systems, Saint Paul, MN, USA. ^[15] Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA. ^[16] Department of Microbiology and Immunology, Schulich School of Medicine & Dentistry, The University of Western Ontario, London, Ontario, Canada. ^[17] Department of Pathology and Laboratory Medicine, Emory Vaccine Center, Yerkes National Primate Research Center, Atlanta, GA, USA. cderdey@emory.edu. ^[18] Department of Pathology and Laboratory Medicine, Emory Vaccine Center, Yerkes National Primate Research Center, Atlanta, GA, USA. ehunte4@emory.edu. ^[19] Department of Microbiology and Immunology, Center for Immunology, University of Minnesota, Minneapolis, MN, USA. masopust@umn.edu. ^[20] Department of Microbiology and Immunology, Emory Vaccine Center, Yerkes National Primate Research Center at Emory University, Atlanta, GA, USA. ramara@emory.edu. ^[21] Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford University, Stanford, CA, USA. bpulend@stanford.edu.;Department of Pathology, Stanford University School of Medicine, Stanford University, Stanford, CA, USA. bpulend@stanford.edu.;Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford University, Stanford, CA, USA. bpulend@stanford.edu. ^[22]