A co-formulation of supramolecularly stabilized insulin and pramlintide enhances mealtime glucagon suppression in diabetic pigs.

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作者： Caitlin L,Maikawa ^[1] ; Anton A A,Smith ^[2] ; Lei,Zou ^[3] ; Gillie A,Roth ^[4] ; Emily C,Gale ^[1] ; Lyndsay M,Stapleton ^[5] ; Sam W,Baker ^[1] ; Joseph L,Mann ^[6] ; Anthony C,Yu ^[2] ; Santiago,Correa ^[2] ; Abigail K,Grosskopf ^[2] ; Celine S,Liong ^[7] ; Catherine M,Meis ^[1] ; Doreen,Chan ^[2] ; Megan,Troxell ^[8] ; David M,Maahs ^[9] ; Bruce A,Buckingham ^[10] ; Matthew J,Webber ^[11] ; Eric A,Appel ^[10]

作者单位： Department of Bioengineering, Stanford University, Stanford, CA, USA. ^[1] Department of Materials Science and Engineering, Stanford University, Stanford, CA, USA. ^[2] Department of Science and Technology, Aarhus University, Aarhus, Denmark. ^[3] Department of Chemical and Biomolecular Engineering, University of Notre Dame, Notre Dame, IN, USA. ^[4] Department of Biochemistry, Stanford University, Stanford, CA, USA. ^[5] Department of Comparative Medicine, Stanford University, Stanford, CA, USA. ^[6] Department of Chemical Engineering, Stanford University, Stanford, CA, USA. ^[7] Department of Chemistry, Stanford University, Stanford, CA, USA. ^[8] Department of Pathology, Stanford University, Stanford, CA, USA. ^[9] Department of Pediatrics (Endocrinology), Stanford University, Stanford, CA, USA. ^[10] Diabetes Research Center, Stanford University, Stanford, CA, USA. ^[11] Department of Bioengineering, Stanford University, Stanford, CA, USA. eappel@stanford.edu. ^[12] Department of Materials Science and Engineering, Stanford University, Stanford, CA, USA. eappel@stanford.edu. ^[13] Department of Pediatrics (Endocrinology), Stanford University, Stanford, CA, USA. eappel@stanford.edu. ^[14] Diabetes Research Center, Stanford University, Stanford, CA, USA. eappel@stanford.edu. ^[15]

主题词动物(Animals);糖尿病, 实验性(Diabetes Mellitus, Experimental);扩散(Diffusion);投药途径(Drug Administration Routes);药物调剂(Drug Compounding);药物稳定性(Drug Stability);胰高血糖素(Glucagon);氢离子浓度(Hydrogen-Ion Concentration);咪唑类(Imidazoles);胰岛素(Insulin);胰岛淀粉样多肽(Islet Amyloid Polypeptide);男(雄)性(Male);聚乙烯二醇类(Polyethylene Glycols);大鼠, Sprague-Dawley(Rats, Sprague-Dawley);信号传导(Signal Transduction);猪(Swine)

DOI 10.1038/s41551-020-0555-4

PMID 32393892

发布时间 2023-11-11

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Nature biomedical engineering

2020年4卷5期

507-517页

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A co-formulation of supramolecularly stabilized insulin and pramlintide enhances mealtime glucagon suppression in diabetic pigs.

Nature biomedical engineering

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Nature biomedical engineering

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A co-formulation of supramolecularly stabilized insulin and pramlintide enhances mealtime glucagon suppression in diabetic pigs.

Nature biomedical engineering

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Nature biomedical engineering

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