A small molecule G6PD inhibitor reveals immune dependence on pentose phosphate pathway.-论文-万方医学网

第一作者： Jonathan M,Ghergurovich

第一单位： Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.

作者： Jonathan M,Ghergurovich ^[1] ; Juan C,García-Cañaveras ^[2] ; Joshua,Wang ^[1] ; Emily,Schmidt ^[3] ; Zhaoyue,Zhang ^[3] ; Tara,TeSlaa ^[1] ; Harshel,Patel ^[3] ; Li,Chen ^[1] ; Emily C,Britt ^[3] ; Marta,Piqueras-Nebot ^[1] ; Mari Carmen,Gomez-Cabrera ^[3] ; Agustín,Lahoz ^[1] ; Jing,Fan ^[3] ; Ulf H,Beier ^[1] ; Hahn,Kim ^[3] ; Joshua D,Rabinowitz ^[4]

作者单位： Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA. ^[1] Department of Molecular Biology, Princeton University, Princeton, NJ, USA. ^[2] Department of Chemistry, Princeton University, Princeton, NJ, USA. ^[3] Morgridge Institute for Research, Department of Nutritional Sciences, University of Wisconsin-Madison, Madison, WI, USA. ^[4] Biomarkers and Precision Medicine Unit, Instituto de Investigación Sanitaria Fundación Hospital La Fe, Valencia, Spain. ^[5] Freshage Research Group, Department of Physiology, Faculty of Medicine, University of Valencia, Valencia, Spain. ^[6] Centro de Investigación Biomédica en Red Fragilidad y Envejecimiento Saludable, Fundación Investigación Hospital Clínico Universitario/INCLIVA, Valencia, Spain. ^[7] Division of Nephrology, Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA, USA. ^[8] Princeton University Small Molecule Screening Center, Princeton University, Princeton, NJ, USA. ^[9] Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA. joshr@princeton.edu. ^[10] Department of Chemistry, Princeton University, Princeton, NJ, USA. joshr@princeton.edu. ^[11]

主题词动物(Animals);细胞系(Cell Line);去氢表雄酮(Dehydroepiandrosterone);剂量效应关系, 药物(Dose-Response Relationship, Drug);酶测定(Enzyme Assays);酶抑制剂(Enzyme Inhibitors);葡萄糖(Glucose);葡糖磷酸脱氢酶(Glucosephosphate Dehydrogenase);糖酵解(Glycolysis);HCT116细胞(HCT116 Cells);Hep G2细胞(Hep G2 Cells);人类(Humans);免疫, 先天(Immunity, Innate);淋巴细胞活化(Lymphocyte Activation);淋巴细胞(Lymphocytes);巨噬细胞活化(Macrophage Activation);巨噬细胞(Macrophages);NADP(NADP);中性白细胞(Neutrophils);磷酸戊糖途径(Pentose Phosphate Pathway)

DOI 10.1038/s41589-020-0533-x

PMID 32393898

发布时间 2021-02-16

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A small molecule G6PD inhibitor reveals immune dependence on pentose phosphate pathway.

Nature chemical biology

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A small molecule G6PD inhibitor reveals immune dependence on pentose phosphate pathway.

Nature chemical biology

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Nature chemical biology

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