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Metformin Enhances Autophagy and Normalizes Mitochondrial Function to Alleviate Aging-Associated Inflammation.

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作者单位: Department of Nutrition and Public Health, Merrimack College, North Andover, MA, USA. [1] Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, KY, USA; Barnstable Brown Diabetes and Obesity Center, University of Kentucky, Lexington, KY, USA. [2] Department of Obstetrics, Gynecology, and Reproductive Sciences, School of Medicine, University of California, San Diego, San Diego, CA, USA. [3] Forsyth Institute, Cambridge, MA, USA. [4] Department of Computer Science, University of Kentucky, Lexington, KY, USA. [5] Department of Physiology, University of Kentucky, Lexington, KY, USA. [6] Department of Pharmaceutical Sciences, University of Kentucky, Lexington, KY, USA. [7] Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, KY, USA. [8] Department of Medicine, Endocrinology, Diabetes & Nutrition, Boston University School of Medicine, Boston, MA, USA. [9] Department of Microbiology, Boston University School of Medicine, Boston, MA, USA; Flow Cytometry Core Facility, Boston University School of Medicine, Boston, MA, USA. [10] Department of Statistics, University of Kentucky, Lexington, KY, USA. [11] Departments of Neurosurgery and Pharmacology, Pennsylvania State University College of Medicine, Hershey, PA, USA. [12] Flow Cytometry Core Facility, Boston University School of Medicine, Boston, MA, USA. [13] Flow Cytometry Core Facility, Boston University School of Medicine, Boston, MA, USA; Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA, USA. [14] Department of Computer Science, University of Kentucky, Lexington, KY, USA; School of Biomedical Informatics, University of Texas Health Science Center at Houston, Houston, TX, USA. [15] Departments of Neurosurgery and Pharmacology, Pennsylvania State University College of Medicine, Hershey, PA, USA; Departments of Biomedical Engineering, and Engineering Science & Mechanics and Center for Neural Engineering, Pennsylvania State University, University Park, PA, USA. [16] Barnstable Brown Diabetes and Obesity Center, University of Kentucky, Lexington, KY, USA; Department of Medicine, University of Kentucky, Lexington, KY, USA. [17] Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, KY, USA; Barnstable Brown Diabetes and Obesity Center, University of Kentucky, Lexington, KY, USA. Electronic address: barb.nik@uky.edu. [18]
DOI 10.1016/j.cmet.2020.04.015
PMID 32402267
发布时间 2022-08-21
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