Polyethylene Glycol 40-Modified Peptide with High Therapeutic Efficacy in Simian-Human Immunodeficiency Virus-Acutely Infected Rhesus Monkeys.

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第一作者： Mingli,Li

第一单位： CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Chaoyang District, Beijing, China.;Savaid Medical School, University of Chinese Academy of Sciences, Huairou District, Beijing, China.

作者： Mingli,Li ^[1] ; Shuihong,Cheng ^[1] ; Yibo,Ding ^[2] ; Chen,Wang ^[2] ; Yong,Feng ^[1] ; Wenzhao,Wang ^[3] ; Liying,Ma ^[4] ; Xuebing,Li ^[5]

作者单位： CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Chaoyang District, Beijing, China.;Savaid Medical School, University of Chinese Academy of Sciences, Huairou District, Beijing, China. ^[1] State Key Laboratory for Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Changping District, Beijing, China. ^[2] State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Chaoyang District, Beijing, China. ^[3] State Key Laboratory for Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Changping District, Beijing, China mal@chinaaids.cn lixb@im.ac.cn. ^[4] CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Chaoyang District, Beijing, China mal@chinaaids.cn lixb@im.ac.cn.;Savaid Medical School, University of Chinese Academy of Sciences, Huairou District, Beijing, China. ^[5]

关键词 HIV inhibitor discovery anti-HIV fusion peptide peptide therapeutics chemical modification to extend half-life pharmacokinetics