HKB99, an allosteric inhibitor of phosphoglycerate mutase 1, suppresses invasive pseudopodia formation and upregulates plasminogen activator inhibitor-2 in erlotinib-resistant non-small cell lung cancer cells.

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第一作者： Qian,Liang

第一单位： Department of Pharmacology and Chemical Biology, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.

作者： Qian,Liang ^[1] ; Wei-Ming,Gu ^[2] ; Ke,Huang ^[1] ; Ming-Yu,Luo ^[2] ; Jing-Hua,Zou ^[3] ; Guang-Lei,Zhuang ^[1] ; Hui-Min,Lei ^[2] ; Hong-Zhuan,Chen ^[1] ; Liang,Zhu ^[2] ; Lu,Zhou ^[4] ; Ying,Shen ^[1]

作者单位： Department of Pharmacology and Chemical Biology, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. ^[1] Shanghai Collaborative Innovation Center for Translational Medicine, Shanghai, 200025, China. ^[2] Department of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai, 201203, China. ^[3] State Key Laboratory of Oncogenes and Related Genes, Department of Obstetrics and Gynecology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200240, China. ^[4] Institute of Interdisciplinary Integrative Biomedical Research, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China. ^[5] Department of Pharmacology and Chemical Biology, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. zhuliang17@126.com. ^[6] Shanghai Collaborative Innovation Center for Translational Medicine, Shanghai, 200025, China. zhuliang17@126.com. ^[7] Department of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai, 201203, China. zhoulu@fudan.edu.cn. ^[8] Department of Pharmacology and Chemical Biology, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. yshen0510@sjtu.edu.cn. ^[9] Shanghai Collaborative Innovation Center for Translational Medicine, Shanghai, 200025, China. yshen0510@sjtu.edu.cn. ^[10]

关键词 HKB99 allosteric inhibitor erlotinib resistance non-small cell lung cancer phosphoglycerate mutase 1 plasminogen activator inhibitor-2