Development of an Enzyme-Mediated, Site-Specific Method to Conjugate Toll-Like Receptor 2 Agonists onto Protein Antigens: Toward a Broadly Protective, Four Component, Group A Streptococcal Self-Adjuvanting Lipoprotein-Fusion Combination Vaccine.

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作者： Zhenghui,Xu ^[1] ; Tania,Rivera-Hernandez ^[2] ; Peter Michael,Moyle ^[3]

作者单位： School of Pharmacy, The University of Queensland, 20 Cornwall Street, Woolloongabba, Queensland 4102, Australia. ^[1] Australian Infectious Diseases Research Centre and School of Chemistry and Molecular Biosciences, The University of Queensland, St. Lucia, Queensland 4072, Australia. ^[2] Cátedras CONACYT - Unidad de Investigación Médica en Inmunoquímica, Hospital de Especialidades del Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City 06720, México. ^[3]

关键词 Group A Streptococcus Toll-like receptor conjugation folded protein antigen self-adjuvanting sortase A-mediated ligation

主题词佐剂, 免疫(Adjuvants, Immunologic);动物(Animals);脂蛋白类(Lipoproteins);小鼠(Mice);酿脓链球菌(Streptococcus pyogenes);Toll样受体2(Toll-Like Receptor 2);疫苗, 联合(Vaccines, Combined)

DOI 10.1021/acsinfecdis.0c00047

PMID 32407620

发布时间 2021-06-23

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ACS infectious diseases

2020年6卷7期

1770-1782页

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Development of an Enzyme-Mediated, Site-Specific Method to Conjugate Toll-Like Receptor 2 Agonists onto Protein Antigens: Toward a Broadly Protective, Four Component, Group A Streptococcal Self-Adjuvanting Lipoprotein-Fusion Combination Vaccine.

ACS infectious diseases

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Development of an Enzyme-Mediated, Site-Specific Method to Conjugate Toll-Like Receptor 2 Agonists onto Protein Antigens: Toward a Broadly Protective, Four Component, Group A Streptococcal Self-Adjuvanting Lipoprotein-Fusion Combination Vaccine.

ACS infectious diseases

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ACS infectious diseases

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