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Triterpenoid CDDO-Me induces ROS generation and up-regulates cellular levels of antioxidative enzymes without induction of DSBs in human peripheral blood mononuclear cells.

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第一作者： Christina,Beinke

第一单位： Bundeswehr Institute of Radiobiology Affiliated to the University Ulm, Neuherbergstr. 11, 80937, Munich, Germany. christinabeinke@bundeswehr.org.

作者： Christina,Beinke ^[1] ; Harry,Scherthan ^[2] ; Matthias,Port ^[2] ; Tanja,Popp ^[2] ; Cornelius,Hermann ^[2] ; Stefan,Eder ^[3]

作者单位： Bundeswehr Institute of Radiobiology Affiliated to the University Ulm, Neuherbergstr. 11, 80937, Munich, Germany. christinabeinke@bundeswehr.org. ^[1] Bundeswehr Institute of Radiobiology Affiliated to the University Ulm, Neuherbergstr. 11, 80937, Munich, Germany. ^[2] Bundeswehr Institute of Radiobiology Affiliated to the University Ulm, Neuherbergstr. 11, 80937, Munich, Germany.;Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, Inner City Clinic, University Hospital of Munich (LMU), Munich, Germany. ^[3]

关键词 Antioxidant Bardoxolone-methyl CDDO-me DNA damage Micronucleus assay Radioprotective activity γ-H2AX foci analysis