Natural Compounds as Pharmaceuticals: The Key Role of Cytochromes P450 Reactivity.

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作者： Giovanna,Di Nardo ^[1] ; Gianfranco,Gilardi ^[2]

作者单位： Department of Life Sciences and Systems Biology, University of Torino, Via Accademia Albertina 13, 10123, Torino, Italy. ^[1] Department of Life Sciences and Systems Biology, University of Torino, Via Accademia Albertina 13, 10123, Torino, Italy. Electronic address: gianfranco.gilardi@unito.it. ^[2]

关键词 CYPs biocatalysis drug leads late-stage functionalization natural products

主题词生物催化(Biocatalysis);生物制品(Biological Products);细胞色素P450酶系统(Cytochrome P-450 Enzyme System);氧化还原(Oxidation-Reduction);药用制剂(Pharmaceutical Preparations);蛋白质工程(Protein Engineering);底物特异性(Substrate Specificity)

DOI 10.1016/j.tibs.2020.03.004

PMID 32413326

发布时间 2021-06-21

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