Age, Inflammation, and Disease Location Are Critical Determinants of Intestinal Expression of SARS-CoV-2 Receptor <i>ACE2</i> and <i>TMPRSS2</i> in Inflammatory Bowel Disease.

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第一作者： Jan Krzysztof,Nowak

第一单位： Translational Gastroenterology Unit, Nuffield Department of Medicine, Experimental Medicine Division, University of Oxford, John Radcliffe Hospital, Oxford, UK; Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Poznan, Poland. Electronic address: jan.nowak@ump.edu.pl.

作者： Jan Krzysztof,Nowak ^[1] ; Jonas Christoffer,Lindstrøm ^[2] ; Rahul,Kalla ^[3] ; Petr,Ricanek ^[4] ; Jonas,Halfvarson ^[5] ; Jack,Satsangi ^[6]

作者单位： Translational Gastroenterology Unit, Nuffield Department of Medicine, Experimental Medicine Division, University of Oxford, John Radcliffe Hospital, Oxford, UK; Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Poznan, Poland. Electronic address: jan.nowak@ump.edu.pl. ^[1] Health Services Research Unit, Akershus University Hospital, Lørenskog, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway. ^[2] MRC Centre for Inflammation Research, Queens Medical Research Institute, University of Edinburgh, Edinburgh, UK. ^[3] Department of Gastroenterology, Akershus University Hospital, Lørenskog, Norway. ^[4] Department of Gastroenterology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden. ^[5] Translational Gastroenterology Unit, Nuffield Department of Medicine, Experimental Medicine Division, University of Oxford, John Radcliffe Hospital, Oxford, UK; Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK. Electronic address: jack.satsangi@ndm.ox.ac.uk. ^[6]

关键词 ACE2, angiotensin-converting enzyme 2 CD, Crohn’s disease CI, confidence interval COVID-19, Coronavirus Disease 2019 IBD, inflammatory bowel disease SARS-CoV-2, severe acute respiratory syndrome coronavirus-2 TMPRSS2, transmembrane serine protease 2 UC, ulcerative colitis hsCRP, high-sensitivity C-reactive protein