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Baseline demographic, clinical, and cognitive characteristics of the Alzheimer's Prevention Initiative (API) Autosomal-Dominant Alzheimer's Disease Colombia Trial.

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第一作者： Silvia,Rios-Romenets

第一单位： Neurosciences Group of Antioquia/University of Antioquia, Medellin, Colombia.

作者： Silvia,Rios-Romenets ^[1] ; Francisco,Lopera ^[1] ; Kaycee M,Sink ^[2] ; Nan,Hu ^[2] ; Qinshu,Lian ^[2] ; Heather,Guthrie ^[2] ; Jillian,Smith ^[3] ; William,Cho ^[2] ; Howard,Mackey ^[2] ; Jessica B,Langbaum ^[4] ; Ronald G,Thomas ^[5] ; Margarita,Giraldo-Chica ^[1] ; Carlos,Tobon ^[1] ; Natalia,Acosta-Baena ^[1] ; Claudia,Muñoz ^[1] ; Paula,Ospina ^[1] ; Victoria,Tirado ^[1] ; Eliana,Henao ^[1] ; Yamile,Bocanegra ^[1] ; Kewei,Chen ^[4] ; Yi,Su ^[4] ; Dhruman,Goradia ^[4] ; Pradeep,Thiyyagura ^[4] ; Paul S,VanGilder ^[4] ; Ji,Luo ^[4] ; Valentina,Ghisays ^[4] ; Wendy,Lee ^[4] ; Michael H,Malek-Ahmadi ^[4] ; Hillary D,Protas ^[4] ; Yinghua,Chen ^[4] ; Yakeel T,Quiroz ^[6] ; Eric M,Reiman ^[4] ; Pierre N,Tariot ^[4] ; the API ADAD Colombia Trial Group ^[1]

作者单位： Neurosciences Group of Antioquia/University of Antioquia, Medellin, Colombia. ^[1] Genentech Inc., South San Francisco, California, USA. ^[2] Roche Products Ltd, Welwyn Garden City, UK. ^[3] Banner Alzheimer's Institute, Phoenix, Arizona, USA. ^[4] University of California, San Diego, California, USA. ^[5] Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts, USA. ^[6]

关键词 Alzheimer's Prevention Initiative Alzheimer's disease autosomal-dominant Alzheimer's disease baseline data clinical trial crenezumab preclinical preclinical Alzheimer's disease prevention

医学主题词成年人(Adult);阿尔茨海默病(Alzheimer Disease);认知(Cognition);女(雌)性(Female);人类(Humans);男(雄)性(Male);中年人(Middle Aged);突变(Mutation);神经心理学测验(Neuropsychological Tests);早老素1(Presenilin-1)

DOI 10.1002/alz.12109

PMID 32418361

发布时间 2021-06-01

基金项目

R01 AG058468/AG/NIA NIH HHS/United States R01 AG055444/AG/NIA NIH HHS/United States UF1 AG046150/AG/NIA NIH HHS/United States RF1 AG041705/AG/NIA NIH HHS/United States P30 AG019610/AG/NIA NIH HHS/United States

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