γ-Secretase modulators exhibit selectivity for modulation of APP cleavage but inverse γ-secretase modulators do not.

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作者： Christian B,Lessard ^[1] ; Edgardo,Rodriguez ^[2] ; Thomas B,Ladd ^[1] ; Lisa M,Minter ^[3] ; Barbara A,Osborne ^[3] ; Lucio,Miele ^[4] ; Todd E,Golde ^[5] ; Yong,Ran ^[6]

作者单位： Department of Neuroscience and Neurology, Center for Translational Research in Neurodegenerative Disease, and McKnight Brain Institute, College of Medicine, University of Florida, 1275 Center Drive, PO Box 100159, Gainesville, FL, 32610, USA. ^[1] Department of Pharmacology and Therapeutics, Center for Translational Research in Neurodegenerative Disease, and McKnight Brain Institute, University of Florida, Gainesville, FL, 32610, USA. ^[2] Department of Veterinary and Animal Sciences, Center for Bioactive Delivery, Institute for Applied Life Sciences, and Program in Molecular and Cellular Biology, University of Massachusetts, Amherst, MA, 01003, USA. ^[3] Department of Genetics and Stanley S. Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans, LA, 70112, USA. ^[4] Department of Neuroscience and Neurology, Center for Translational Research in Neurodegenerative Disease, and McKnight Brain Institute, College of Medicine, University of Florida, 1275 Center Drive, PO Box 100159, Gainesville, FL, 32610, USA. tgolde@ufl.edu. ^[5] Department of Neuroscience and Neurology, Center for Translational Research in Neurodegenerative Disease, and McKnight Brain Institute, College of Medicine, University of Florida, 1275 Center Drive, PO Box 100159, Gainesville, FL, 32610, USA. yran@ufl.edu. ^[6]

关键词 Alzheimer’s disease Amyloid peptide Amyloid protein precursor (APP)Cancer Gene knockout NOTCH Presenilin VEGFR1 γ-Secretase modulators (GSMs)

主题词淀粉样前体蛋白分泌酶类(Amyloid Precursor Protein Secretases);淀粉样β肽类(Amyloid beta-Peptides);淀粉样β蛋白前体(Amyloid beta-Protein Precursor);HEK293细胞(HEK293 Cells);人类(Humans);早老素2(Presenilin-2);信号传导(Signal Transduction)

DOI 10.1186/s13195-020-00622-5

PMID 32430033

发布时间 2021-06-24

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