The prohibitin-binding compound fluorizoline affects multiple components of the translational machinery and inhibits protein synthesis.

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作者： Xin,Jin ^[1] ; Jianling,Xie ^[2] ; Michael,Zabolocki ^[1] ; Xuemin,Wang ^[1] ; Tao,Jiang ^[3] ; Dong,Wang ^[1] ; Laurent,Désaubry ^[4] ; Cedric,Bardy ^[2] ; Christopher G,Proud ^[5]

作者单位： Lifelong Health Theme, South Australian Health & Medical Research Institute, Adelaide, Australia. ^[1] Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology and School of Medicine and Pharmacy, Ocean University of China, Qingdao, China. ^[2] Laboratory for Human Neurophysiology and Genetics, College of Medicine and Public Health, Flinders University, Adelaide, Australia. ^[3] School of Biological Sciences, University of Adelaide, Adelaide, Australia. ^[4] Sino-French Joint Lab of Food Nutrition/Safety and Medicinal Chemistry, College of Biotechnology, Tianjin University of Science and Technology, Tianjin, China. ^[5] Laboratory of Medicinal Chemistry and Cardio-oncology, CNRS, Strasbourg, France. ^[6] Lifelong Health Theme, South Australian Health & Medical Research Institute, Adelaide, Australia Christopher.Proud@sahmri.com. ^[7]

关键词 calcium cancer cell death eEF2 eIF2 elongation endoplasmic reticulum stress (ER stress)eukaryotic initiation factor 2 (eIF2)eukaryotic translation initiation initiation prohibitin protein synthesis translation elongation factor