Self-assembling influenza nanoparticle vaccines drive extended germinal center activity and memory B cell maturation.

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作者： Hannah G,Kelly ^[1] ; Hyon-Xhi,Tan ^[2] ; Jennifer A,Juno ^[1] ; Robyn,Esterbauer ^[1] ; Yi,Ju ^[1] ; Wenbo,Jiang ^[2] ; Verena C,Wimmer ^[2] ; Brigette C,Duckworth ^[3] ; Joanna R,Groom ^[1] ; Frank,Caruso ^[4] ; Masaru,Kanekiyo ^[5] ; Stephen J,Kent ^[5] ; Adam K,Wheatley ^[2]

作者单位： Department of Microbiology and Immunology, University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia. ^[1] ARC Centre of Excellence in Convergent Bio-Nano Science and Technology and. ^[2] Department of Chemical Engineering, University of Melbourne, Parkville, Victoria, Australia. ^[3] Centre for Dynamic Imaging and. ^[4] Division of Immunology, Walter and Eliza Hall Institute of Medical Research, Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia. ^[5] Vaccine Research Center, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, Maryland, USA. ^[6] Melbourne Sexual Health Centre and Department of Infectious Diseases, Alfred Hospital and Central Clinical School, Monash University, Melbourne, Victoria, Australia. ^[7]

关键词 Adaptive immunity Immunology Influenza Nanotechnology Vaccines

主题词动物(Animals);B-淋巴细胞(B-Lymphocytes);女(雌)性(Female);生发中心(Germinal Center);血凝素糖蛋白类, 流感病毒(Hemagglutinin Glycoproteins, Influenza Virus);免疫记忆(Immunologic Memory);流感疫苗(Influenza Vaccines);豚尾猴(Macaca nemestrina);小鼠(Mice);纳米粒子(Nanoparticles);T淋巴细胞, 辅助诱导(T-Lymphocytes, Helper-Inducer)

DOI 10.1172/jci.insight.136653

PMID 32434990

发布时间 2021-05-18

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Self-assembling influenza nanoparticle vaccines drive extended germinal center activity and memory B cell maturation.

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Self-assembling influenza nanoparticle vaccines drive extended germinal center activity and memory B cell maturation.

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