Truncation of Pik3r1 causes severe insulin resistance uncoupled from obesity and dyslipidaemia by increased energy expenditure.-论文-万方医学网

第一作者： Albert,Kwok

第一单位： The University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Cambridge, UK; MRC Metabolic Diseases Unit, Wellcome Trust-MRC Institute of Metabolic Science, Cambridge, UK.

作者： Albert,Kwok ^[1] ; Ilona,Zvetkova ^[1] ; Sam,Virtue ^[1] ; Ineke,Luijten ^[2] ; Isabel,Huang-Doran ^[1] ; Patsy,Tomlinson ^[1] ; David A,Bulger ^[1] ; James,West ^[3] ; Steven,Murfitt ^[3] ; Julian,Griffin ^[4] ; Rafeah,Alam ^[5] ; Daniel,Hart ^[1] ; Rachel,Knox ^[1] ; Peter,Voshol ^[6] ; Antonio,Vidal-Puig ^[1] ; Jørgen,Jensen ^[7] ; Stephen,O'Rahilly ^[1] ; Robert K,Semple ^[8]

作者单位： The University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Cambridge, UK; MRC Metabolic Diseases Unit, Wellcome Trust-MRC Institute of Metabolic Science, Cambridge, UK. ^[1] Centre for Cardiovascular Science, University of Edinburgh, 47 Little France Crescent, Edinburgh, UK. ^[2] Department of Biochemistry and Cambridge Systems Biology Centre, University of Cambridge, Cambridge, UK. ^[3] Department of Biochemistry and Cambridge Systems Biology Centre, University of Cambridge, Cambridge, UK; Biomolecular Medicine, Division of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Medicine, Imperial College London, The Sir Alexander Fleming Building, London, UK. ^[4] Laboratory of Lymphocyte Signalling and Development, The Babraham Institute, Cambridge, UK. ^[5] Louis Bolk Institute, Kosterijland 3-5, NL-3981 AJ, Bunnik, the Netherlands. ^[6] Department of Physical Performance, Norwegian School of Sport Sciences, P.O. Box 4014, Ulleval Stadion, 0806 Oslo, Norway. ^[7] Centre for Cardiovascular Science, University of Edinburgh, 47 Little France Crescent, Edinburgh, UK; The University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Cambridge, UK; MRC Metabolic Diseases Unit, Wellcome Trust-MRC Institute of Metabolic Science, Cambridge, UK. Electronic address: rsemple@ed.ac.uk. ^[8]

医学主题词脂肪组织, 棕色(Adipose Tissue, Brown);体脂肪率(Adiposity);动物(Animals);Ia类磷脂酰肌醇3-激酶(Class Ia Phosphatidylinositol 3-Kinase);血脂异常(Dyslipidemias);能量代谢(Energy Metabolism);脂肪肝(Fatty Liver);生长障碍(Growth Disorders);高钙血症(Hypercalcemia);炎症(Inflammation);胰岛素(Insulin);胰岛素抗药性(Insulin Resistance);脂肪生成(Lipogenesis);肝(Liver);男(雄)性(Male);代谢疾病(Metabolic Diseases);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);肾钙质沉着症(Nephrocalcinosis);肥胖症(Obesity);磷酸肌醇3-激酶类(Phosphatidylinositol 3-Kinases)

DOI 10.1016/j.molmet.2020.101020

PMID 32439336

发布时间 2025-05-30

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Truncation of Pik3r1 causes severe insulin resistance uncoupled from obesity and dyslipidaemia by increased energy expenditure.

Molecular metabolism

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Molecular metabolism

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Truncation of Pik3r1 causes severe insulin resistance uncoupled from obesity and dyslipidaemia by increased energy expenditure.

Molecular metabolism

相似文献

同项目论文

Molecular metabolism

相关期刊

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