Impaired mesocorticolimbic connectivity underlies increased pain sensitivity in chronic low back pain.

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作者： Siyi,Yu ^[1] ; Wen,Li ^[2] ; Wei,Shen ^[1] ; Robert R,Edwards ^[3] ; Randy L,Gollub ^[1] ; Georgia,Wilson ^[1] ; Joel,Park ^[1] ; Ana,Ortiz ^[1] ; Jin,Cao ^[1] ; Jessica,Gerber ^[4] ; Ishtiaq,Mawla ^[1] ; Suk-Tak,Chan ^[4] ; Jeungchan,Lee ^[4] ; Ajay D,Wasan ^[5] ; Vitaly,Napadow ^[4] ; Ted J,Kaptchuk ^[6] ; Bruce,Rosen ^[4] ; Jian,Kong ^[7]

作者单位： Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA. ^[1] Department of Psychology, Florida State University, Tallahassee, FL, USA. ^[2] Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. ^[3] Department of Radiology, Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA. ^[4] Department of Anesthesiology, Center for Pain Research, University of Pittsburgh, Pittsburgh, PA, USA. ^[5] Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. ^[6] Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA; Department of Radiology, Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA. Electronic address: jkong2@mgh.harvard.edu. ^[7]

关键词 Central sensitization Functional connectivity Low back pain Mesocorticolimbic network Pain sensitivity Quantitative sensory testing Reward network Ventral tegmental area