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Genotoxicity of aldehyde mixtures: profile of exocyclic DNA-adducts as a biomarker of exposure to tobacco smoke.

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第一作者： Héléna,Alamil

第一单位： Normandie University, UNICAEN, ABTE EA4651, Caen, France; CCC François Baclesse, UNICANCER, Caen, France; L2GE, Microbiology-Tox/Ecotox Team, Faculty of Sciences, Lebanese University, Fanar, Lebanon. Electronic address: helena.alamil@unicaen.fr.

作者： Héléna,Alamil ^[1] ; Laurence,Galanti ^[2] ; Natacha,Heutte ^[3] ; Marie,Van Der Schueren ^[4] ; Zeina,Dagher ^[5] ; Mathilde,Lechevrel ^[6]

作者单位： Normandie University, UNICAEN, ABTE EA4651, Caen, France; CCC François Baclesse, UNICANCER, Caen, France; L2GE, Microbiology-Tox/Ecotox Team, Faculty of Sciences, Lebanese University, Fanar, Lebanon. Electronic address: helena.alamil@unicaen.fr. ^[1] Tabacology Unit, CHU UCL Namur Asbl, Belgium. ^[2] CCC François Baclesse, UNICANCER, Caen, France; Normandie University, UNIROUEN, CETAPS EA3832, Mont Saint Aignan, Cedex, France. ^[3] Tabacology Unit, Department of Addictology, CHU Caen Normandie, France. ^[4] L2GE, Microbiology-Tox/Ecotox Team, Faculty of Sciences, Lebanese University, Fanar, Lebanon. ^[5] Normandie University, UNICAEN, ABTE EA4651, Caen, France; CCC François Baclesse, UNICANCER, Caen, France. Electronic address: mathilde.lechevrel@unicaen.fr. ^[6]

关键词 Adducts Aldehydes Biomarkers Oxidative stress Tobacco smoke UHPLC-ESI-MS/MS

医学主题词醛类(Aldehydes);DNA(DNA);DNA加合物(DNA Adducts);剂量效应关系, 药物(Dose-Response Relationship, Drug);人类(Humans);诱变剂(Mutagens);吸烟(Smoking)

DOI 10.1016/j.toxlet.2020.05.010

PMID 32442718

发布时间 2024-12-05

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