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Study protocol: improving cognition in people with progressive multiple sclerosis: a multi-arm, randomized, blinded, sham-controlled trial of cognitive rehabilitation and aerobic exercise (COGEx).

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第一作者： Anthony,Feinstein

第一单位： Department of Psychiatry, University of Toronto and Sunnybrook Health Sciences Centre, Toronto, ON, M5R 3B6, Canada.

作者： Anthony,Feinstein ^[1] ; Maria Pia,Amato ^[2] ; Giampaolo,Brichetto ^[3] ; Jeremy,Chataway ^[4] ; Nancy,Chiaravalloti ^[5] ; Ulrik,Dalgas ^[6] ; John,DeLuca ^[5] ; Peter,Feys ^[7] ; Massimo,Filippi ^[8] ; Jennifer,Freeman ^[9] ; Cecilia,Meza ^[1] ; Matilde,Inglese ^[10] ; Robert W,Motl ^[11] ; Maria Assunta,Rocca ^[12] ; Brian M,Sandroff ^[11] ; Amber,Salter ^[13] ; Gary,Cutter ^[14] ; CogEx Research Team

作者单位： Department of Psychiatry, University of Toronto and Sunnybrook Health Sciences Centre, Toronto, ON, M5R 3B6, Canada. ^[1] Department NEUROFARBA, Section Neurosciences, University of Florence, Largo Brambilla 3, 50134, Florence, Italy.;IRCCS Fondazione Don Carlo Gnocchi, Florence, Italy. ^[2] Scientific Research Area, Italian Multiple Sclerosis Foundation (FISM), Via Operai 40, 16149, Genoa, Italy.;AISM Rehabilitation Service, Italian Multiple Sclerosis Society (AISM), Via Operai 30, 16149, Genoa, Italy. ^[3] Queen Square MS Centre, Department of Neuroinflammation, University College London (UCL) Queen Square Institute of Neurology, Faculty of Brain Sciences, UCL, London, UK. ^[4] Kessler Foundation, East Hanover, NJ, USA.;Department of Physical Medicine & Rehabilitation, Rutgers New Jersey Medical School, Newark, NJ, USA. ^[5] Section for Sport Science, Department of Public Health, Aarhus University, Dalgas Avenue 4, DK-8000, Aarhus, Denmark. dalgas@ph.au.dk. ^[6] Faculty of Rehabilitation Sciences, Hasselt University, Diepenbeek, Belgium. ^[7] Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, and Neurology unit, IRCCS, San Raffaele Scientific Institute, Via Olgettina 60, 20132, Milan, Italy.;Vita-Salute San Raffaele University, Milan, Italy. ^[8] Faculty of Health: Medicine, Dentistry and Human Sciences, University of Plymouth, Devon, UK. ^[9] Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), and Center of Excellence for Biomedical Research, University of Genoa, Genoa, Italy. ^[10] Department of Physical Therapy, University of Alabama at Birmingham, Birmingham, USA. ^[11] Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, and Neurology unit, IRCCS, San Raffaele Scientific Institute, Via Olgettina 60, 20132, Milan, Italy. ^[12] Division of Biostatistics, Washington University School of Medicine, St. Louis, MO, USA. ^[13] Department of Biostatistics, University of Alabama at Birmingham, Birmingham, USA. ^[14]

关键词 Aerobic exercise Cognitive training Progressive multiple sclerosis

医学主题词运动(Exercise)(Exercise);运动疗法(Exercise Therapy);人类(Humans);多发性硬化, 慢性进行性(Multiple Sclerosis, Chronic Progressive);神经心理学测验(Neuropsychological Tests);随机对照试验(主题)(Randomized Controlled Trials as Topic)

DOI 10.1186/s12883-020-01772-7

PMID 32443981

发布时间 2026-01-09

基金项目

3185/Multiple Sclerosis Society of Canada SI-1905-34071/National Multiple Sclerosis Society

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