换一批Regulatory cell therapy in kidney transplantation (The ONE Study): a harmonised design and analysis of seven non-randomised, single-arm, phase 1/2A trials.
第一作者：
Birgit,Sawitzki
第一单位：
Institute of Medical Immunology, Charité, Universitätsmedizin Berlin, Berlin, Germany.
作者：
Birgit,Sawitzki [1]
;
Paul N,Harden [2]
;
Petra,Reinke [3]
;
Aurélie,Moreau [4]
;
James A,Hutchinson [5]
;
David S,Game [6]
;
Qizhi,Tang [7]
;
Eva C,Guinan [8]
;
Manuela,Battaglia [9]
;
William J,Burlingham [10]
;
Ian S D,Roberts [11]
;
Mathias,Streitz [12]
;
Régis,Josien [13]
;
Carsten A,Böger [14]
;
Cristiano,Scottà [15]
;
James F,Markmann [16]
;
Joanna L,Hester [17]
;
Karsten,Juerchott [18]
;
Cecile,Braudeau [13]
;
Ben,James [19]
;
Laura,Contreras-Ruiz [20]
;
Jeroen B,van der Net [2]
;
Tobias,Bergler [14]
;
Rossana,Caldara [21]
;
William,Petchey [2]
;
Matthias,Edinger [22]
;
Nathalie,Dupas [23]
;
Michael,Kapinsky [24]
;
Ingrid,Mutzbauer [19]
;
Natalie M,Otto [3]
;
Robert,Öllinger [25]
;
Maria P,Hernandez-Fuentes [15]
;
Fadi,Issa [17]
;
Norbert,Ahrens [26]
;
Christoph,Meyenberg [27]
;
Sandra,Karitzky [28]
;
Ulrich,Kunzendorf [29]
;
Stuart J,Knechtle [30]
;
Josep,Grinyó [31]
;
Peter J,Morris [32]
;
Leslie,Brent [33]
;
Andrew,Bushell [17]
;
Laurence A,Turka [16]
;
Jeffrey A,Bluestone [34]
;
Robert I,Lechler [15]
;
Hans J,Schlitt [5]
;
Maria C,Cuturi [4]
;
Stephan,Schlickeiser [12]
;
Peter J,Friend [35]
;
Tewfik,Miloud [23]
;
Alexander,Scheffold [36]
;
Antonio,Secchi [37]
;
Kerry,Crisalli [16]
;
Sang-Mo,Kang [7]
;
Rachel,Hilton [6]
;
Bernhard,Banas [14]
;
Gilles,Blancho [4]
;
Hans-Dieter,Volk [12]
;
Giovanna,Lombardi [15]
;
Kathryn J,Wood [17]
;
Edward K,Geissler [38]
作者单位：
Institute of Medical Immunology, Charité, Universitätsmedizin Berlin, Berlin, Germany.
[1]
Oxford Transplantation Centre, Oxford University Hospitals NHS Foundation Trust, University of Oxford, Oxford, UK.
[2]
BeCAT, BCRT, and Department of Nephrology & Intensive Care, Charité Universitätsmedizin Berlin, and Berlin Institute of Health, Berlin, Germany.
[3]
Centre de Recherche en Transplantation et Immunologie, Nantes Université, Inserm, Nantes, France; Institute of Transplantation Urology Nephrology, Nantes, France.
[4]
Department of Surgery, University of Regensburg, University Hospital Regensburg, Regensburg, Germany.
[5]
Guy's & St Thomas' NHS Foundation Trust, Guy's Hospital, London, UK.
[6]
Division of Transplantation, Department of Surgery, University of California, San Francisco, San Francisco, CA, USA.
[7]
Department of Radiation Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston MA, USA.
[8]
Diabetes Research Institute, Istituto di Ricovero e Cura a Carattere Scientifico, San Raffaele Scientific Institute, Milan, Italy.
[9]
Division of Transplantation, Department of Surgery, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.
[10]
Department of Cellular Pathology, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
[11]
Institute of Medical Immunology, Charité, Universitätsmedizin Berlin, Berlin, Germany; BIH Center for Regenerative Therapies, Charité and Berlin Institute of Health, Charité, Universitätsmedizin Berlin, Berlin, Germany.
[12]
Centre de Recherche en Transplantation et Immunologie, Nantes Université, Inserm, Nantes, France; Institute of Transplantation Urology Nephrology, Nantes, France; Laboratoire d'Immunologie, Cimna, Centre Hospitalier Universitaire, Nantes, France.
[13]
Department of Nephrology, University of Regensburg, University Hospital Regensburg, Regensburg, Germany.
[14]
MRC Centre for Transplantation, Peter Gorer Department of Immunobiology, School of Immunology & Microbial Sciences, King's College London, London, UK.
[15]
Center for Transplantation Sciences, Mass General Hospital, Boston, MA, USA.
[16]
Transplantation Research and Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK.
[17]
BIH Center for Regenerative Therapies, Charité and Berlin Institute of Health, Charité, Universitätsmedizin Berlin, Berlin, Germany.
[18]
Department of Surgery, University of Regensburg, University Hospital Regensburg, Regensburg, Germany; Division of Personalized Tumor Therapy, Fraunhofer Institute for Experimental Medicine and Toxicology, Regensburg, Germany.
[19]
Department of Experimental Medicine, DFCI, Boston, MA, USA.
[20]
Transplant Medicine, Istituto di Ricovero e Cura a Carattere Scientifico, San Raffaele Scientific Institute, Milan, Italy.
[21]
Department of Internal Medicine III, University of Regensburg, University Hospital Regensburg, Regensburg, Germany; Regensburg Center for Interventional Immunology, University of Regensburg, Regensburg, Germany.
[22]
Beckman Coulter Life Sciences, Immunotech, Marseille, France.
[23]
Beckman Coulter, Krefeld, Germany.
[24]
Department of Surgery, Charité Campus Mitte, Campus Virchow Klinikum, Charité Universitätsmedizin, Berlin, Germany.
[25]
Institute for Clinical Chemistry and Laboratory Medicine, Transfusion Medicine, University of Regensburg, University Hospital Regensburg, Regensburg, Germany.
[26]
KOEHLER eClinical, Freiburg, Germany.
[27]
Miltenyi Biotec, Bergisch Gladbach, Germany.
[28]
Clinic for Nephrology and Hypertension, Christian Albrechts University, University Clinic Schleswig-Holstein, Kiel, Germany.
[29]
Department of Surgery, Duke Transplant Center, Duke University Medical Center, Durham, NC, USA.
[30]
Kidney Transplant Unit, Nephrology Department, Bellvitge University Hospital, IDIBELL, Barcelona University, Barcelona, Spain.
[31]
Centre for Evidence in Transplantation, Clinical Effectiveness Unit, Royal College of Surgeons of England, London, UK; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK.
[32]
St Mary's Hospital Transplant Unit, Paddington, London, UK.
[33]
UCSF Diabetes Center, University of California, San Francisco, San Francisco, CA, USA.
[34]
Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK.
[35]
Institute for Immunology, Christian Albrechts University, University Clinic Schleswig-Holstein, Kiel, Germany.
[36]
Vita-Salute San Raffaele University Milan, Istituto di Ricovero e Cura a Carattere Scientifico, San Raffaele Scientific Institute, Milan, Italy.
[37]
Department of Surgery, University of Regensburg, University Hospital Regensburg, Regensburg, Germany; Division of Personalized Tumor Therapy, Fraunhofer Institute for Experimental Medicine and Toxicology, Regensburg, Germany; Regensburg Center for Interventional Immunology, University of Regensburg, Regensburg, Germany. Electronic address: edward.geissler@klinik.uni-regensburg.de.
[38]
医学主题词
树突细胞(Dendritic Cells);移植物排斥(Graft Rejection);人类(Humans);免疫抑制剂(Immunosuppressive Agents);肾移植(Kidney Transplantation);巨噬细胞(Macrophages);T淋巴细胞, 调节性(T-Lymphocytes, Regulatory)
DOI
10.1016/S0140-6736(20)30167-7
PMID
32446407
发布时间
2025-05-30
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Lancet (London, England)
Lancet (London, England)
1627-1639页
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