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N-Quinary heterocycle-4-sulphamoylbenzamides exert anti-hypoxic effects as dual inhibitors of carbonic anhydrases I/II.

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第一作者： Chaofu,Yang

第一单位： State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, 27 Taiping Road, Haidian District, Beijing 100850, China; College of Chemistry & Pharmacy, Shaanxi Key Laboratory of Natural Products& Chemical Biology, Northwest A&F University, Yangling, Shaanxi 712100, China.

作者： Chaofu,Yang ^[1] ; Jing,Wang ^[2] ; Yunyun,Cheng ^[2] ; Xu,Yang ^[2] ; Yan,Feng ^[2] ; Xiaomei,Zhuang ^[2] ; Zhenwang,Li ^[3] ; Wangyu,Zhao ^[4] ; Jiwen,Zhang ^[4] ; Xianyu,Sun ^[5] ; Xinhua,He ^[6]

作者单位： State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, 27 Taiping Road, Haidian District, Beijing 100850, China; College of Chemistry & Pharmacy, Shaanxi Key Laboratory of Natural Products& Chemical Biology, Northwest A&F University, Yangling, Shaanxi 712100, China. ^[1] State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, 27 Taiping Road, Haidian District, Beijing 100850, China. ^[2] Department of Pharmacy, College of Animal Science and Technique, Heilongjiang Bayi Agricultural University, Xinyang Road 2, Daqing 163319, China. ^[3] College of Chemistry & Pharmacy, Shaanxi Key Laboratory of Natural Products& Chemical Biology, Northwest A&F University, Yangling, Shaanxi 712100, China. ^[4] Department of Pharmacy, College of Animal Science and Technique, Heilongjiang Bayi Agricultural University, Xinyang Road 2, Daqing 163319, China. Electronic address: sxianyu@163.com. ^[5] State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, 27 Taiping Road, Haidian District, Beijing 100850, China. Electronic address: xhhe@ncba.ac.cn. ^[6]

关键词 Anti-hypoxic activity Docking simulation Dual hCA I/II inhibitor Human carbonic anhydrase N-quinary heterocycle-4-sulphamoylbenzamide