Design and rationale of a randomized, placebo-controlled trial on the efficacy and safety of sulodexide for extended treatment in elderly patients after a first venous thromboembolism.

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作者： Gualtiero,Palareti ^[1] ; Cristina,Legnani ^[2] ; Emilia,Antonucci ^[2] ; Serena,Zorzi ^[2] ; Angelo A,Bignamini ^[3] ; Corrado,Lodigiani ^[4] ; Alberto,Tosetto ^[5] ; Lorenza,Bertù ^[6] ; Vittorio,Pengo ^[7] ; Sophie,Testa ^[8] ; Walter,Ageno ^[9] ; Domenico,Prisco ^[10] ; Paolo,Prandoni ^[2] ; Daniela,Poli ^[11]

作者单位： Arianna Anticoagulazione" Foundation, Via Paolo Fabbri 1/3, 40138, Bologna, Italy. gualtiero.palareti@unibo.it. ^[1] Arianna Anticoagulazione" Foundation, Via Paolo Fabbri 1/3, 40138, Bologna, Italy. ^[2] Department of Pharmaceutical Sciences, School of Specialization in Hospital Pharmacy, University of Milan, Milan, Italy. ^[3] Thrombosis and Hemorrhagic Diseases Unit, Humanitas Research Hospital and Humanitas University, Rozzano (Milan), Italy. ^[4] Divisione Di Ematologia, Centro Malattie Emorragiche E Trombotiche, AULSS8 Berica, Vicenza, Italy. ^[5] Centro Di Ricerca Sulle Malattie Tromboemboliche E Le Terapie Antitrombotiche, Università Degli Studi dell'Insubria, Varese, Italy. ^[6] Thrombosis Research Laboratory, Department of Cardiac-Thoracic-Vascular Sciences and Public Health, University of Padua, Padua, Italy. ^[7] Department of Laboratory Medicine, Haemostasis and Thrombosis Center, AO Istituti Ospitalieri, Cremona, Italy. ^[8] Dipartimento Di Medicina E Chirurgia, Università Degli Studi Dell'Insubria, Varese, Italy. ^[9] DMSC Università Di Firenze, SOD Medicina Interna Interdisciplinare, AOU Careggi, Florence, Italy. ^[10] Centro Trombosi, Azienda Ospedaliera Careggi, Florence, Italy. ^[11]

关键词 Elderly Extension Recurrence Sulodexide Venous thromboembolism