首页> Pharmacological research> Arctiin abrogates osteoclastogenesis and bone resorption via suppressing RANKL-induced ROS and NFATc1 activation.

Arctiin abrogates osteoclastogenesis and bone resorption via suppressing RANKL-induced ROS and NFATc1 activation.

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第一作者： Delong,Chen

第一单位： Department of Orthopaedic Surgery, Clifford Hospital, Jinan University, Guangzhou 510006, China; School of Biomedical Sciences, University of Western Australia, Perth, Western Australia 6009, Australia.

作者： Delong,Chen ^[1] ; Zhen,Ye ^[2] ; Chao,Wang ^[3] ; Qingqing,Wang ^[4] ; Haibin,Wang ^[5] ; Vincent,Kuek ^[3] ; Ziyi,Wang ^[3] ; Heng,Qiu ^[3] ; Jinbo,Yuan ^[3] ; Jacob,Kenny ^[3] ; Fan,Yang ^[6] ; Jianbo,He ^[7] ; Yun,Liu ^[8] ; Gang,Wang ^[7] ; Meng,Zhang ^[9] ; Gangyu,Zhang ^[9] ; Junjian,Wang ^[10] ; Peng,Chen ^[11] ; Jiake,Xu ^[12]

作者单位： Department of Orthopaedic Surgery, Clifford Hospital, Jinan University, Guangzhou 510006, China; School of Biomedical Sciences, University of Western Australia, Perth, Western Australia 6009, Australia. ^[1] The First Affiliated Hospital, Wenzhou Medical University, Wenzhou 325000, China. ^[2] School of Biomedical Sciences, University of Western Australia, Perth, Western Australia 6009, Australia. ^[3] School of Biomedical Sciences, University of Western Australia, Perth, Western Australia 6009, Australia; Department of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310000, China. ^[4] Department of Orthopaedic Surgery, First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou 510405, China. ^[5] The MOE Key Laboratory for Standardization of Chinese Medicines and the SHTCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. ^[6] School of Biomedical Sciences, University of Western Australia, Perth, Western Australia 6009, Australia; Guangzhou University of Chinese Medicine, Guangzhou 510405, China. ^[7] School of Biomedical Sciences, University of Western Australia, Perth, Western Australia 6009, Australia; Department of Spine Osteopathy Surgery, First Affiliated Hospital, Guangxi Medical University, Nanning 530021, China. ^[8] Guangzhou University of Chinese Medicine, Guangzhou 510405, China. ^[9] School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China. ^[10] Department of Orthopaedic Surgery, First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou 510405, China. Electronic address: docchen777@gmail.com. ^[11] School of Biomedical Sciences, University of Western Australia, Perth, Western Australia 6009, Australia. Electronic address: jiake.xu@uwa.edu.au. ^[12]

关键词 Arctiin Bone resorption Osteoclast RANKL-induced NFATc1 activation ROS