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首页> Proceedings of the National Academy of Sciences of the United States of America> A methyl-TROSY approach for NMR studies of high-molecular-weight DNA with application to the nucleosome core particle.

A methyl-TROSY approach for NMR studies of high-molecular-weight DNA with application to the nucleosome core particle.

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第一作者： Gili,Abramov

第一单位： Department of Molecular Genetics, The University of Toronto, Toronto, ON M5S 1A8, Canada.

作者： Gili,Abramov ^[1] ; Algirdas,Velyvis ^[2] ; Enrico,Rennella ^[3] ; Leo E,Wong ^[1] ; Lewis E,Kay ^[2]

作者单位： Department of Molecular Genetics, The University of Toronto, Toronto, ON M5S 1A8, Canada. ^[1] Department of Biochemistry, The University of Toronto, Toronto, ON M5S 1A8, Canada. ^[2] Department of Chemistry, The University of Toronto, Toronto, ON M5S 1A8, Canada. ^[3] Bioscience Department, Syngenta, Jealott's Hill Research Centre, Bracknell RG42 6EY, United Kingdom. ^[4] Department of Molecular Genetics, The University of Toronto, Toronto, ON M5S 1A8, Canada; kay@pound.med.utoronto.ca. ^[5] Program in Molecular Medicine, Hospital for Sick Children, Toronto, ON M5G 1X8, Canada. ^[6]

关键词 CpG methylation high-molecular-weight protein–DNA complexes one-pot synthesis of methyl-labeled DNA structural dynamics of protein–DNA complexes

主题词腺嘌呤(Adenine);碳同位素(Carbon Isotopes);CpG岛(CpG Islands);胞嘧啶(Cytosine);DNA(DNA);DNA甲基化(DNA Methylation);DNA结合蛋白质类(DNA-Binding Proteins);分子动力学模拟(Molecular Dynamics Simulation);分子量(Molecular Weight);核磁共振, 生物分子(Nuclear Magnetic Resonance, Biomolecular);核小体(Nucleosomes);光谱分析(Spectrum Analysis)

DOI 10.1073/pnas.2004317117

PMID 32457157

发布时间 2023-11-11

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Proceedings of the National Academy of Sciences of the United States of America

Proceedings of the National Academy of Sciences of the United States of America

2020年117卷23期

12836-12846页

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Proceedings of the National Academy of Sciences of the United States of America

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Proceedings of the National Academy of Sciences of the United States of America

2020年117卷23期

12836-12846页

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