Tumor ablation plus co-administration of CpG and saponin adjuvants affects IL-1 production and multifunctional T cell numbers in tumor draining lymph nodes.

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作者： Tonke K,Raaijmakers ^[1] ; Renske J E,van den Bijgaart ^[2] ; Martijn H,den Brok ^[1] ; Melissa,Wassink ^[1] ; Annemarie,de Graaf ^[2] ; Jori A,Wagenaars ^[1] ; Stefan,Nierkens ^[1] ; Marleen,Ansems ^[1] ; Gert Jan,Scheffer ^[1] ; Gosse J,Adema ^[3]

作者单位： Radiotherapy and OncoImmunology Laboratory, Department of Radiation Oncology, Radboud University Medical Center, Nijmegen, The Netherlands. ^[1] Department of Anesthesiology, Pain and Palliative Medicine, Radboud University Medical Center, Nijmegen, The Netherlands. ^[2] Center for Translational Immunology, Utrecht University, Utrecht, The Netherlands. ^[3] Radiotherapy and OncoImmunology Laboratory, Department of Radiation Oncology, Radboud University Medical Center, Nijmegen, The Netherlands gosse.adema@radboudumc.nl. ^[4]

关键词 CD8-positive T-lymphocytes adaptive immunity adjuvants, immunologic dendritic cells immunomodulation

主题词佐剂, 免疫(Adjuvants, Immunologic);动物(Animals);导管消融术(Catheter Ablation);综合疗法(Combined Modality Therapy);树突细胞(Dendritic Cells);女(雌)性(Female);白细胞介素1(Interleukin-1);淋巴结(Lymph Nodes);淋巴细胞活化(Lymphocyte Activation);黑色素瘤, 实验性(Melanoma, Experimental);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, 基因敲除(Mice, Knockout);寡脱氧核糖核苷酸类(Oligodeoxyribonucleotides);皂苷类(Saponins);T淋巴细胞(T-Lymphocytes)

DOI 10.1136/jitc-2020-000649

PMID 32461350

发布时间 2021-03-17

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Journal for immunotherapy of cancer

2020年8卷1期

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Tumor ablation plus co-administration of CpG and saponin adjuvants affects IL-1 production and multifunctional T cell numbers in tumor draining lymph nodes.

Journal for immunotherapy of cancer

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Journal for immunotherapy of cancer

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Tumor ablation plus co-administration of CpG and saponin adjuvants affects IL-1 production and multifunctional T cell numbers in tumor draining lymph nodes.

Journal for immunotherapy of cancer

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Journal for immunotherapy of cancer

相关期刊

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