MYC Drives Temporal Evolution of Small Cell Lung Cancer Subtypes by Reprogramming Neuroendocrine Fate.

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第一作者： Abbie S,Ireland

第一单位： Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA.

作者： Abbie S,Ireland ^[1] ; Alexi M,Micinski ^[1] ; David W,Kastner ^[1] ; Bingqian,Guo ^[1] ; Sarah J,Wait ^[1] ; Kyle B,Spainhower ^[1] ; Christopher C,Conley ^[2] ; Opal S,Chen ^[3] ; Matthew R,Guthrie ^[1] ; Danny,Soltero ^[1] ; Yi,Qiao ^[4] ; Xiaomeng,Huang ^[4] ; Szabolcs,Tarapcsák ^[4] ; Siddhartha,Devarakonda ^[5] ; Milind D,Chalishazar ^[1] ; Jason,Gertz ^[1] ; Justin C,Moser ^[6] ; Gabor,Marth ^[4] ; Sonam,Puri ^[7] ; Benjamin L,Witt ^[8] ; Benjamin T,Spike ^[1] ; Trudy G,Oliver ^[9]

作者单位： Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA. ^[1] Huntsman Cancer Institute Bioinformatic Analysis Shared Resource, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA. ^[2] Huntsman Cancer Institute High-Throughput Genomics Shared Resource, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA. ^[3] Utah Center for Genetic Discovery, Eccles Institute of Human Genetics, University of Utah, Salt Lake City, UT 84112, USA. ^[4] Division of Medical Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA. ^[5] HonorHealth Research Institute, Scottsdale, AZ 85254, USA. ^[6] Department of Internal Medicine, University of Utah, Salt Lake City, UT 84112, USA. ^[7] Department of Pathology, University of Utah, Salt Lake City, UT 84112, USA; ARUP Laboratories at University of Utah, Salt Lake City, UT 84108, USA. ^[8] Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA. Electronic address: trudy.oliver@hci.utah.edu. ^[9]

关键词 ASCL1 MYC NEUROD1 NOTCH SCLC YAP1 mouse models neuroendocrine plasticity tumor evolution