Human PSC-Derived Hepatocytes Express Low Levels of Viral Pathogen Recognition Receptors, but Are Capable of Mounting an Effective Innate Immune Response.
第一作者:
Lena,Fischer
第一单位:
School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.
作者:
医学主题词
抗病毒药(Antiviral Agents);细胞分化(Cell Differentiation);细胞质(Cytoplasm);胚胎干细胞(Embryonic Stem Cells);内颗粒(Endosomes);肝细胞(Hepatocytes);人类(Humans);免疫, 先天(Immunity, Innate);诱导多能干细胞(Induced Pluripotent Stem Cells);炎症(Inflammation);Janus激酶类(Janus Kinases);配体(Ligands);显微镜检查, 荧光(Microscopy, Fluorescence);受体, 模式识别(Receptors, Pattern Recognition);受体, 病毒(Receptors, Virus);信号传导(Signal Transduction);Toll样受体(Toll-Like Receptors);肿瘤坏死因子α(Tumor Necrosis Factor-alpha);增量调节(Up-Regulation)
DOI
10.3390/ijms21113831
PMID
32481600
发布时间
2025-05-30
基金项目
TCS/16/37/CSO_/Chief Scientist Office/United Kingdom
CSO TCS/16/37/CSO_/Chief Scientist Office/United Kingdom
12/IA/1667./SFI_/Science Foundation Ireland/Ireland
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