Skeletal muscle enhancer interactions identify genes controlling whole-body metabolism.-论文-万方医学网

作者： Kristine,Williams ^[1] ; Lars R,Ingerslev ^[1] ; Jette,Bork-Jensen ^[1] ; Martin,Wohlwend ^[2] ; Ann Normann,Hansen ^[1] ; Lewin,Small ^[1] ; Rasmus,Ribel-Madsen ^[1] ; Arne,Astrup ^[3] ; Oluf,Pedersen ^[1] ; Johan,Auwerx ^[2] ; Christopher T,Workman ^[4] ; Niels,Grarup ^[1] ; Torben,Hansen ^[1] ; Romain,Barrès ^[5]

作者单位： Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. ^[1] Laboratory of Integrative and Systems Physiology, Interfaculty Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. ^[2] Department of Nutrition, Exercise and Sports Science, Faculty of Science, University of Copenhagen, Copenhagen, Denmark. ^[3] Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark. ^[4] Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. barres@sund.ku.dk. ^[5]

主题词动物(Animals);细胞系(Cell Line);染色质(Chromatin);糖尿病, 2型(Diabetes Mellitus, Type 2);增强子元件, 遗传学(Enhancer Elements, Genetic);女(雌)性(Female);基因表达谱(Gene Expression Profiling);全基因组关联研究(Genome-Wide Association Study);人类(Humans);胰岛素抗药性(Insulin Resistance);男(雄)性(Male);小鼠(Mice);肌纤维, 骨骼(Muscle Fibers, Skeletal);肌, 骨骼(Muscle, Skeletal);肥胖症(Obesity);棕榈酸(Palmitic Acid);肽起始因子类(Peptide Initiation Factors);多态性, 单核苷酸(Polymorphism, Single Nucleotide);启动区, 遗传(Promoter Regions, Genetic);肿瘤坏死因子α(Tumor Necrosis Factor-alpha)

DOI 10.1038/s41467-020-16537-6

PMID 32483258

发布时间 2021-06-01

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Skeletal muscle enhancer interactions identify genes controlling whole-body metabolism.

Nature communications

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Skeletal muscle enhancer interactions identify genes controlling whole-body metabolism.

Nature communications

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Nature communications

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