An Isoform-Selective Modulator of Cryptochrome 1 Regulates Circadian Rhythms in Mammals.

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第一作者： Simon,Miller

第一单位： Institute of Transformative Bio-Molecules, Nagoya University, Nagoya 464-8601, Japan.

作者： Simon,Miller ^[1] ; Yoshiki,Aikawa ^[1] ; Akiko,Sugiyama ^[1] ; Yoshiko,Nagai ^[1] ; Aya,Hara ^[1] ; Tsuyoshi,Oshima ^[2] ; Kazuma,Amaike ^[2] ; Steve A,Kay ^[3] ; Kenichiro,Itami ^[2] ; Tsuyoshi,Hirota ^[4]

作者单位： Institute of Transformative Bio-Molecules, Nagoya University, Nagoya 464-8601, Japan. ^[1] Institute of Transformative Bio-Molecules, Nagoya University, Nagoya 464-8601, Japan; Department of Chemistry, Graduate School of Science, Nagoya University, Nagoya 464-8601, Japan. ^[2] Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA. ^[3] Institute of Transformative Bio-Molecules, Nagoya University, Nagoya 464-8601, Japan. Electronic address: thirota@itbm.nagoya-u.ac.jp. ^[4]

关键词 X-ray crystallography chemical biology circadian clock cryptochrome small-molecule modulator

主题词 ARNTL转录因子类(ARNTL Transcription Factors);结合部位(Binding Sites);卡唑类(Carbazoles);细胞系, 肿瘤(Cell Line, Tumor);昼夜节律(Circadian Rhythm);隐花色素类(Cryptochromes);结晶学, X线(Crystallography, X-Ray);F框蛋白质类(F-Box Proteins);基因, 报告(Genes, Reporter);人类(Humans);周期昼夜节律蛋白质类(Period Circadian Proteins);蛋白质结合(Protein Binding);构效关系(Structure-Activity Relationship);泛素化(Ubiquitination)

DOI 10.1016/j.chembiol.2020.05.008

PMID 32502390

发布时间 2023-12-13

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Cell chemical biology

2020年27卷9期

1192-1198.e5页

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An Isoform-Selective Modulator of Cryptochrome 1 Regulates Circadian Rhythms in Mammals.

Cell chemical biology

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An Isoform-Selective Modulator of Cryptochrome 1 Regulates Circadian Rhythms in Mammals.

Cell chemical biology

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