Characterization of a reliable cell-based reporter gene assay for measuring bioactivities of therapeutic anti-interleukin-23 monoclonal antibodies.

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作者： Jing,Huang ^[1] ; Lan,Wang ^[2] ; Chuanfei,Yu ^[2] ; Zhihao,Fu ^[2] ; Chunyu,Liu ^[2] ; Hongmei,Zhang ^[3] ; Kaiqin,Wang ^[2] ; Xiao,Guo ^[2] ; Junzhi,Wang ^[4]

作者单位： School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, No. 103 Wenhua Road, Shenyang, Liaoning, 110016,China; Key Laboratory of the Ministry of Health for Research on Quality and Standardization of Biotech Products, National Institutes for Food and Drug Control, No. 2, Tiantan Xili, Dongcheng District, Beijing, 100050, China. ^[1] Key Laboratory of the Ministry of Health for Research on Quality and Standardization of Biotech Products, National Institutes for Food and Drug Control, No. 2, Tiantan Xili, Dongcheng District, Beijing, 100050, China. ^[2] Key Laboratory of the Ministry of Health for Research on Quality and Standardization of Biotech Products, National Institutes for Food and Drug Control, No. 2, Tiantan Xili, Dongcheng District, Beijing, 100050, China; School of Pharmacy, Yantai University, No, 30 Qingquan Road, Yantai, Shandong, 264005, China. ^[3] School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, No. 103 Wenhua Road, Shenyang, Liaoning, 110016,China; Key Laboratory of the Ministry of Health for Research on Quality and Standardization of Biotech Products, National Institutes for Food and Drug Control, No. 2, Tiantan Xili, Dongcheng District, Beijing, 100050, China. Electronic address: wangjz_nifdc2014@163.com. ^[4]

关键词 Bioactivity IL-23 Monoclonal antibody Reporter gene assay