首页> Neuroscience bulletin> Blockade of HCN2 Channels Provides Neuroprotection Against Ischemic Injury via Accelerating Autophagic Degradation in Hippocampal Neurons.

Blockade of HCN2 Channels Provides Neuroprotection Against Ischemic Injury via Accelerating Autophagic Degradation in Hippocampal Neurons.

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第一作者： Cheng,Chen

第一单位： Department of Pharmacology, School of Basic Medical Sciences, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.

作者： Cheng,Chen ^[1] ; Li,Liu ^[2] ; Ya-Qiao,Shu ^[1] ; Ping,Jing ^[3] ; Yun,Lu ^[4] ; Xiao-Xue,Zhang ^[5] ; Xian-Gang,Zong ^[6] ; Lian-Jun,Guo ^[7] ; Chang-Jun,Li ^[8]

作者单位： Department of Pharmacology, School of Basic Medical Sciences, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. ^[1] Office of Academic Research, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. ^[2] Department of Neurology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. ^[3] Department of Pharmacy, Zhongnan Hospital of Wuhan University, Wuhan, 430030, China. ^[4] Department of Clinical Laboratory, Wuhan PuAi Hospital, Wuhan, 430033, China. ^[5] Center for Integrated Protein Science and Zentrum für Pharmaforschung, Department Pharmazie, Ludwig-Maximilians-Universität München, 80539, Munich, Germany. ^[6] Department of Pharmacology, School of Basic Medical Sciences, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. gljyl1518@126.com.;Key Laboratory of Drug Target Research and Pharmacodynamic Evaluation, Wuhan, 430030, China. gljyl1518@126.com. ^[7] Department of Neurology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. hydlcj@163.com. ^[8]

关键词 Autophagy HCN2 channel Neuroprotection Oxygen-glucose deprivation/reperfusion Transient global cerebral ischemia