Chromatin Priming Renders T Cell Tolerance-Associated Genes Sensitive to Activation below the Signaling Threshold for Immune Response Genes.

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第一作者： Sarah L,Bevington

第一单位： Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, UK.

作者： Sarah L,Bevington ^[1] ; Sky T H,Ng ^[2] ; Graham J,Britton ^[3] ; Peter,Keane ^[1] ; David C,Wraith ^[4] ; Peter N,Cockerill ^[5]

作者单位： Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, UK. ^[1] Institute of Immunology and Immunotherapy, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, UK. ^[2] Precision Immunology Institute and Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. ^[3] Institute of Immunology and Immunotherapy, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, UK. Electronic address: d.wraith@bham.ac.uk. ^[4] Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, UK. Electronic address: p.n.cockerill@bham.ac.uk. ^[5]

关键词 CTLA4 Cbl-b IL-10 T cell chromatin epigenetic gene regulation signaling tolerance transcription factor