The BMP Receptor 2 in Pulmonary Arterial Hypertension: When and Where the Animal Model Matches the Patient.

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作者： Chris,Happé ^[1] ; Kondababu,Kurakula ^[2] ; Xiao-Qing,Sun ^[1] ; Denielli,da Silva Goncalves Bos ^[1] ; Nina,Rol ^[1] ; Christophe,Guignabert ^[3] ; Ly,Tu ^[4] ; Ingrid,Schalij ^[3] ; Karien C,Wiesmeijer ^[4] ; Olga,Tura-Ceide ^[1] ; Anton,Vonk Noordegraaf ^[2] ; Frances S,de Man ^[5] ; Harm Jan,Bogaard ^[6] ; Marie-José,Goumans ^[7]

作者单位： Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Pulmonology, Amsterdam Cardiovascular Sciences, 1081 HV Amsterdam, The Netherlands. ^[1] Laboratory for Cardiovascular Cell Biology, Department of Cell and Chemical Biology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands. ^[2] INSERM UMR_S 999, Hôpital Marie Lannelongue, 92350 Le Plessis-Robinson, France. ^[3] Université Paris-Saclay, School of Medicine, 94270 Le Kremlin-Bicêtre, France. ^[4] Department of Pulmonary Medicine, Hospital Clínic-Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), University of Barcelona, 08036 Barcelona, Spain. ^[5] Biomedical Research Networking center on Respiratory diseases (CIBERES), 28029 Madrid, Spain. ^[6] Department of Pulmonary Medicine, Dr. Josep Trueta University Hospital de Girona, Santa Caterina Hospital de Salt and the Girona Biomedical Research Institut (IDIBGI), 17190 Girona, Catalonia, Spain. ^[7]

关键词 BMP and TGF-β signaling BMPR2 animal models of pulmonary hypertension pulmonary arterial hypertension

主题词动物(Animals);骨形态发生蛋白受体, Ⅱ型(Bone Morphogenetic Protein Receptors, Type II);疾病模型, 动物(Disease Models, Animal);人类(Humans);肺(Lung);男(雄)性(Male);模型, 生物学(Models, Biological);磷酰化(Phosphorylation);大鼠, Wistar(Rats, Wistar);Smad蛋白质类(Smad Proteins)

DOI 10.3390/cells9061422

PMID 32521690

发布时间 2021-03-02

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Cells

2020年9卷6期

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The BMP Receptor 2 in Pulmonary Arterial Hypertension: When and Where the Animal Model Matches the Patient.

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The BMP Receptor 2 in Pulmonary Arterial Hypertension: When and Where the Animal Model Matches the Patient.

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