Targeting CD33 in Chemoresistant AML Patient-Derived Xenografts by CAR-CIK Cells Modified with an Improved SB Transposon System.

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作者： Maria Caterina,Rotiroti ^[1] ; Chiara,Buracchi ^[1] ; Silvia,Arcangeli ^[1] ; Stefania,Galimberti ^[2] ; Maria Grazia,Valsecchi ^[2] ; Vincenzo Maria,Perriello ^[3] ; Tamas,Rasko ^[4] ; Gaia,Alberti ^[1] ; Chiara Francesca,Magnani ^[1] ; Claudia,Cappuzzello ^[1] ; Felix,Lundberg ^[5] ; Amit,Pande ^[4] ; Giuseppe,Dastoli ^[1] ; Martino,Introna ^[6] ; Marta,Serafini ^[1] ; Ettore,Biagi ^[1] ; Zsuzsanna,Izsvák ^[4] ; Andrea,Biondi ^[7] ; Sarah,Tettamanti ^[1]

作者单位： Tettamanti Research Center, Department of Pediatrics, University of Milano-Bicocca/Fondazione MBBM, 20900 Monza, Italy. ^[1] Center of Biostatistics for Clinical Epidemiology, School of Medicine and Surgery, University of Milano - Bicocca, 20900 Monza, Italy. ^[2] Tettamanti Research Center, Department of Pediatrics, University of Milano-Bicocca/Fondazione MBBM, 20900 Monza, Italy; Università degli Studi di Perugia, 06123 Perugia, Italy. ^[3] Max-Delbrück-Centrum für Molekulare Medizin in the Helmholtz Association (MDC), 13125 Berlin, Germany. ^[4] Max-Delbrück-Centrum für Molekulare Medizin in the Helmholtz Association (MDC), 13125 Berlin, Germany; The Milner Centre for Evolution, University of Bath, BA2 7AY Bath, UK. ^[5] Center of Cellular Therapy "G. Lanzani," USC Ematologia ASST Papa Giovanni XXIII, 24124 Bergamo, Italy. ^[6] Tettamanti Research Center, Department of Pediatrics, University of Milano-Bicocca/Fondazione MBBM, 20900 Monza, Italy. Electronic address: abiondi.unimib@gmail.com. ^[7]

关键词 AML CAR CD33 Sleeping Beauty transposon cytokine-induced killer cells immunotherapy non-viral gene transfer