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Sirt3 is a novel target to treat sepsis induced myocardial dysfunction by acetylated modulation of critical enzymes within cardiac tricarboxylic acid cycle.

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第一作者： Yinchuan,Xu

第一单位： Department of Cardiology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310000, China.

作者： Yinchuan,Xu ^[1] ; Shujing,Zhang ^[2] ; Jiabing,Rong ^[1] ; Yao,Lin ^[3] ; Linlin,Du ^[3] ; Yi,Wang ^[4] ; Zhaocai,Zhang ^[5]

作者单位： Department of Cardiology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310000, China. ^[1] College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China. ^[2] Department of Intensive Care Unit, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310000, China. ^[3] College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China. Electronic address: zjuwangyi@zju.edu.cn. ^[4] Department of Intensive Care Unit, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310000, China. Electronic address: 2313003@zju.edu.cn. ^[5]

关键词 Cardiac tricarboxylic acid cycle Emodin Emodin (PubChem CID: 3220)Hyper-acetylation Lactate Sepsis induced myocardial dysfunction Sirt3