换一批Characterization of organic anion transporting polypeptide 1b2 knockout rats generated by CRISPR/Cas9: a novel model for drug transport and hyperbilirubinemia disease.
第一作者：
Xinrun,Ma
第一单位：
Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai 200241, China.
作者：
关键词
A/G, albumin/globulin ratioADRs, adverse drug reactionsALB, albuminALP, alkaline phosphataseALT, alanine aminotransferaseAST, aspartate aminotransferaseAUC, the area under the time–plasma concentration curveBUN, blood urea nitrogenCL/F, clearance/bioavailabilityCR, reatinineCRISPR, clustered regularly interspaced short palindromic repeatsCRISPR/Cas9Chr, chromosomeCmax, peak concentrationDAB, 3,3′-diaminobenzidineDBL, direct bilirubinDDI, drug–drug interactionDMSO, dimethyl sulfoxideFDA, the U.S. Food and Drug AdministrationGAPDH, glyceraldehyde 3-phosphate dehydrogenaseGLB, globulinGLU, glucoseHCG, human chorionic gonadotropinHDL-C, high density lipoprotein cholesterolHE, haemotoxylin and eosinHMG, hydroxymethylglutarylHRP, horseradish peroxidaseHZ, heterozygousIBIL, indirect bilirubinIS, internal standard solutionKO, knockoutLDL-C, low density lipoprotein cholesterolMC, methylcelluloseMRT, mean residence timeNC, nitrocelluloseOATP1B1/3OATP1B1/3, organic anion transporting polypeptide 1B1 and 1B3OATP1B2OATPs, organic anion transporting polypeptidesPAM, protospacer adjacent motifPMSG, pregnant mare serum gonadotropinR-GT, γ-glutamyltranspeptidaseRat modelSD, Sprague–DawleySDS-PAGE, sodium dodecyl sulfate polyacrylamide gel electrophoresisSLC, solute carrierSNPs, single nucleotide polymorphismsT-CH, total cholesterolT7E I, T7 endonuclease ITALEN, transcription activator-like effector nucleaseTBA, total bile acidTBL, total bilirubinTBST, Tris-buffered saline Tween 20TG, triglycerideTP, total proteinTmax, peak timeTransporterUA, uric acidUgt1a1, UDP glucuronosyltransferase family 1 member A1Vd/F, the apparent volume of distribution/bioavailabilityWT, wild typeZFN, zinc-finger nucleasescrRNA, mature CRISPR RNAp.o., peroralsgRNA, single guide RNA
DOI
10.1016/j.apsb.2019.11.007
PMID
32528832
发布时间
2020-09-28
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Acta pharmaceutica Sinica. B
2020年10卷5期
850-860页
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