Bacterial citrullinated epitopes generated by <i>Porphyromonas gingivalis</i> infection-a missing link for ACPA production.

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作者： Madeleine,Jenning ^[1] ; Bianka,Marklein ^[1] ; Jimmy,Ytterberg ^[2] ; Roman A,Zubarev ^[3] ; Vijay,Joshua ^[4] ; Dirkjan,van Schaardenburg ^[5] ; Lotte,van de Stadt ^[6] ; Anca Irinel,Catrina ^[7] ; Ute,Nonhoff ^[6] ; Thomas,Häupl ^[7] ; Zoltán,Konthur ^[8] ; Gerd R,Burmester ^[9] ; Karl,Skriner ^[1]

作者单位： Department of Rheumatology and Clinical Immunology, Charité University Medicine Berlin, Corporate Member of Free University Berlin, Humboldt University Berlin and Berlin Institute of Health, Berlin, Germany. ^[1] Swedish Orphan Biovitrum AB, Stockholm, Sweden. ^[2] Department of Medical Biochemistry and Biophysics, Division of Physiological Chemistry I, Stockholm, Sweden. ^[3] Medical Biochemistry and Biophysics, Chemistry I Division, Karolinska Institute, Stockholm, Sweden. ^[4] Rheumatology Unit, Department of Medicine, Karolinska University Hospital and Institutet, Stockholm, Sweden. ^[5] Jan van Breemen Research Institute ^[6] Reade, Amsterdam, The Netherlands. ^[7] Rheumatology Unit, Stockholm, Sweden. ^[8] Engine GmbH, Hennigsdorf, Germany. ^[9] Bundesanstalt für Materialforschung und -prüfung (BAM), Berlin, Germany. ^[10] Department of Rheumatology and Clinical Immunology, Charité University Medicine Berlin, Corporate Member of Free University Berlin, Humboldt University Berlin and Berlin Institute of Health, Berlin, Germany karl.skriner@charite.de. ^[11]

关键词 autoantibodies autoimmunity early rheumatoid arthritis infections