T cell receptor interactions with human leukocyte antigen govern indirect peptide selectivity for the cancer testis antigen MAGE-A4.
作者:
关键词
MAGE-A4T cell receptorT cell receptor (TCR)adaptive immunityantigen presentationantigen recognitioncancer therapycancer-associated antigencrystal structureimmuno-oncologyimmunotherapymelanoma antigen-A4 (MAGE-A4)peptide-human leukocyte antigenpeptide-human leukocyte antigen (pHLA)surface plasmon resonance (SPR)
主题词
抗原, 肿瘤(Antigens, Neoplasm);结晶学, X线(Crystallography, X-Ray);HLA-A2抗原(HLA-A2 Antigen);人类(Humans);模型, 分子(Models, Molecular);肿瘤蛋白质类(Neoplasm Proteins);肽类(Peptides);蛋白质构象(Protein Conformation);受体, 抗原, T细胞, α-β(Receptors, Antigen, T-Cell, alpha-beta)
DOI
10.1074/jbc.RA120.014016
PMID
32532817
发布时间
2021-02-05
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The Journal of biological chemistry
11486-11494页
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