Fibroblast growth factor receptor 4 increases epidermal growth factor receptor (EGFR) signaling by inducing amphiregulin expression and attenuates response to EGFR inhibitors in colon cancer.

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作者： Chang-Soo,Hong ^[1] ; Eun-Gene,Sun ^[1] ; Ji-Na,Choi ^[1] ; Dae-Hwan,Kim ^[1] ; Jo-Heon,Kim ^[2] ; Kyung-Hyun,Ryu ^[3] ; Hyun-Jeong,Shim ^[1] ; Jun-Eul,Hwang ^[1] ; Woo-Kyun,Bae ^[1] ; Hyeong-Rok,Kim ^[4] ; Kyung Keun,Kim ^[5] ; Chaeyong,Jung ^[6] ; Ik-Joo,Chung ^[7] ; Sang-Hee,Cho ^[1]

作者单位： Division of Hematology-Oncology, Department of Internal Medicine, Chonnam National University Hwasun Hospital, Chonnam National University Medical School, Hwasun, Korea. ^[1] Department of Pathology, Chonnam National University Hwasun Hospital, Hwasun, Korea. ^[2] Department of Biological Science, Sookmyung Women's University, Seoul, Korea. ^[3] Combinatorial Tumor Immunotherapy MRC, Chonnam National University Medical School, Hwasun, Korea. ^[4] Department of Surgery, Chonnam National University Hwasun Hospital, Hwasun, Korea. ^[5] Department of Pharmacology, Chonnam National University Medical School, Hwasun, Korea. ^[6] Department of Anatomy, Chonnam National University Medical School, Hwasun, Korea. ^[7]

关键词 AREG EGFR FGFR4 cetuximab colon cancer