High methylation levels of histone H3 lysine 9 associated with activation of hypoxia-inducible factor 1α (HIF-1α) predict patients' worse prognosis in human hepatocellular carcinomas.

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作者： Yanyan,Qian ^[1] ; Yiping,Li ^[2] ; Chuqian,Zheng ^[1] ; Tianyu,Lu ^[1] ; Rui,Sun ^[1] ; Yuhang,Mao ^[1] ; Shenling,Yu ^[1] ; Hong,Fan ^[3] ; Zhihong,Zhang ^[4]

作者单位： Department of Medical Genetics and Developmental Biology, Medical School of Southeast University, The Key Laboratory of Developmental Genes and Human Diseases, Ministry of Education, Southeast University, Nanjing, 210009, China. ^[1] Department of Pathology, Medical School, Southeast University, Nanjing, 210009, China. ^[2] Department of Medical Genetics and Developmental Biology, Medical School of Southeast University, The Key Laboratory of Developmental Genes and Human Diseases, Ministry of Education, Southeast University, Nanjing, 210009, China. Electronic address: fanh@seu.edu.cn. ^[3] Department of Pathology, the First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029, P. R. China. Electronic address: zhangzhih2001@aliyun.com. ^[4]

关键词 H3K9me2 H3K9me3 HCC HIF-1α Prognosis

主题词癌, 肝细胞(Carcinoma, Hepatocellular);细胞核(Cell Nucleus);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);组蛋白类(Histones);人类(Humans);缺氧诱导因子1, α亚基(Hypoxia-Inducible Factor 1, alpha Subunit);肝肿瘤(Liver Neoplasms);赖氨酸(Lysine);甲基化(Methylation);预后(Prognosis);回顾性研究(Retrospective Studies);存活率分析(Survival Analysis);组织阵列分析(Tissue Array Analysis);增量调节(Up-Regulation)

DOI 10.1016/j.cancergen.2020.04.077

PMID 32534446

发布时间 2020-12-17

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Cancer genetics

2020年245卷

17-26页

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High methylation levels of histone H3 lysine 9 associated with activation of hypoxia-inducible factor 1α (HIF-1α) predict patients' worse prognosis in human hepatocellular carcinomas.

Cancer genetics

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Cancer genetics

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High methylation levels of histone H3 lysine 9 associated with activation of hypoxia-inducible factor 1α (HIF-1α) predict patients' worse prognosis in human hepatocellular carcinomas.

Cancer genetics

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Cancer genetics

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