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首页> Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie> Dendrobium nobile Lindl. alkaloids-mediated protection against CCl<sub>4-</sub>induced liver mitochondrial oxidative damage is dependent on the activation of Nrf2 signaling pathway.

Dendrobium nobile Lindl. alkaloids-mediated protection against CCl<sub>4-</sub>induced liver mitochondrial oxidative damage is dependent on the activation of Nrf2 signaling pathway.

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作者： Jinxin,Zhou ^[1] ; Ya,Zhang ^[1] ; Shiyue,Li ^[1] ; Qian,Zhou ^[1] ; Yuanfu,Lu ^[1] ; Jingshan,Shi ^[1] ; Jie,Liu ^[1] ; Qin,Wu ^[2] ; Shaoyu,Zhou ^[3]

作者单位： Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnocentric of Ministry of Education, Zunyi Medical University, Zunyi, Guizhou, 563003, China. ^[1] Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnocentric of Ministry of Education, Zunyi Medical University, Zunyi, Guizhou, 563003, China. Electronic address: wuqinzmc@163.com. ^[2] Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnocentric of Ministry of Education, Zunyi Medical University, Zunyi, Guizhou, 563003, China. Electronic address: szhou20@163.com. ^[3]

关键词 Acute liver injury Carbon tetrachloride Mitochondria Nrf2 Oxidative stress

主题词生物碱类(Alkaloids);动物(Animals);抗氧化剂(Antioxidants);细胞凋亡(Apoptosis);四氯化碳(Carbon Tetrachloride);DNA损伤(DNA Damage);石斛属(Dendrobium);疾病模型, 动物(Disease Models, Animal);肝(Liver);男(雄)性(Male);小鼠, 基因敲除(Mice, Knockout);线粒体, 肝(Mitochondria, Liver);NF-E2相关因子2(NF-E2-Related Factor 2);氧化性应激(Oxidative Stress);活性氧(Reactive Oxygen Species);信号传导(Signal Transduction)

DOI 10.1016/j.biopha.2020.110351

PMID 32535387

发布时间 2021-02-26

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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

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