首页> Clinical epigenetics> Harnessing peripheral DNA methylation differences in the Alzheimer's Disease Neuroimaging Initiative (ADNI) to reveal novel biomarkers of disease.

Harnessing peripheral DNA methylation differences in the Alzheimer's Disease Neuroimaging Initiative (ADNI) to reveal novel biomarkers of disease.

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第一作者： Aparna,Vasanthakumar

第一单位： Genomics Research Center, AbbVie, North Chicago, IL, USA. aparna.vasanthakumar@abbvie.com.

作者： Aparna,Vasanthakumar ^[1] ; Justin W,Davis ^[2] ; Kenneth,Idler ^[2] ; Jeffrey F,Waring ^[2] ; Elizabeth,Asque ^[2] ; Bridget,Riley-Gillis ^[2] ; Shaun,Grosskurth ^[2] ; Gyan,Srivastava ^[3] ; Sungeun,Kim ^[4] ; Kwangsik,Nho ^[5] ; Kelly N H,Nudelman ^[6] ; Kelley,Faber ^[7] ; Yu,Sun ^[8] ; Tatiana M,Foroud ^[7] ; Karol,Estrada ^[9] ; Liana G,Apostolova ^[5] ; Qingqin S,Li ^[8] ; Andrew J,Saykin ^[5] ; Alzheimer’s Disease Neuroimaging Initiative (ADNI)

作者单位： Genomics Research Center, AbbVie, North Chicago, IL, USA. aparna.vasanthakumar@abbvie.com. ^[1] Genomics Research Center, AbbVie, North Chicago, IL, USA. ^[2] Exploratory Statistics, AbbVie, North Chicago, IL, USA. ^[3] Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA.;Electrical and Computer Engineering, State University of New York, Oswego, NY, 13126, USA. ^[4] Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA. ^[5] Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA.;National Centralized Repository for Alzheimer's Disease and Related Dementias, Indiana University School of Medicine, Indianapolis, IN, USA. ^[6] National Centralized Repository for Alzheimer's Disease and Related Dementias, Indiana University School of Medicine, Indianapolis, IN, USA. ^[7] Neuroscience Therapeutic Area, Janssen Research & Development, Pennington, NJ, 08534, USA.;Research Information Technology, Janssen Research & Development, Pennington, NJ, 08534, USA. ^[8] Biogen, Cambridge, MA, 02142, USA.;Currently at Biomarin Pharmaceuticals, Novato, CA, 94949, USA. ^[9]

关键词 ADNI Alzheimer’s disease Biomarker DNA methylation Peripheral blood

医学主题词老年人(Aged);老年人, 80以上(Aged, 80 and over);阿尔茨海默病(Alzheimer Disease);病例对照研究(Case-Control Studies);DNA甲基化(DNA Methylation);诊断, 鉴别(Diagnosis, Differential);疾病恶化(Disease Progression);早期诊断(Early Diagnosis);表观基因组学(Epigenomics);女(雌)性(Female);基因型(Genotype);人类(Humans);纵向研究(Longitudinal Studies);男(雄)性(Male);表型(Phenotype)

DOI 10.1186/s13148-020-00864-y

PMID 32539856

发布时间 2024-02-11

基金项目

U24 AG021886/AG/NIA NIH HHS/United States U01 AG024904/AG/NIA NIH HHS/United States U01 AG024904/NH/NIH HHS/United States U19 AG024904/AG/NIA NIH HHS/United States R01 LM012535/LM/NLM NIH HHS/United States

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